PMID- 1874537
OWN - NLM
STAT- MEDLINE
DCOM- 19910920
LR  - 20131121
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 29
IP  - 3
DP  - 1991 Mar
TI  - Effects of stress on immune responsiveness, gastric ulcerogenesis and plasma 
      corticosterone in rats: modulation by diazepam and naltrexone.
PG  - 233-6
AB  - Effects of restraint stress (24 hr at room temperature) were evaluated on some 
      immunological, visceral and endocrinal responses in rats. In animals sensitized 
      with sheep RBC (SRBC), restraint stress (a) prevented the booster-induced rise in 
      anti-SRBC antibody titre, (b) induced gastric mucosal erosions, and (c) elevated 
      plasma corticosterone, when compared to non-stressed controls. Diazepam (1 or 10 
      mg/kg) consistently attenuated the effects of stress on all three parameters 
      studied. The opioid antagonist, naltrexone (1 or 5 mg/kg) tended to aggravate 
      these stress-induced effects. These concurrent biological changes during stress 
      and their modulation by drugs are discussed in light of a possible correlation 
      between endocrinal, immunological and visceral changes during such aversive 
      stimuli.
FAU - Ray, A
AU  - Ray A
AD  - Department of Pharmacology, University College of Medical Sciences, Delhi, India.
FAU - Mediratta, P K
AU  - Mediratta PK
FAU - Puri, S
AU  - Puri S
FAU - Sen, P
AU  - Sen P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 5S6W795CQM (Naltrexone)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Corticosterone/blood
MH  - Diazepam/pharmacology
MH  - Male
MH  - Naltrexone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stomach Ulcer/prevention & control
MH  - Stress, Physiological/drug therapy/*immunology
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
PST - ppublish
SO  - Indian J Exp Biol. 1991 Mar;29(3):233-6.