PMID- 18752089
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20220318
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 41
IP  - 2
DP  - 2009
TI  - Joint analysis of individual participants' data from 17 studies on the 
      association of the IL6 variant -174G>C with circulating glucose levels, 
      interleukin-6 levels, and body mass index.
PG  - 128-38
LID - 10.1080/07853890802337037 [doi]
AB  - BACKGROUND: Several studies have investigated associations between the -174G>C 
      single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related 
      to type 2 diabetes mellitus (T2DM) but presented inconsistent results. AIMS: This 
      joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose 
      and circulating interleukin-6 concentrations as well as body mass index (BMI). 
      METHODS: Individual-level data from all studies of the IL6-T2DM consortium on 
      Caucasian subjects with available BMI were collected. As study-specific estimates 
      did not show heterogeneity (P>0.1), they were combined by using the 
      inverse-variance fixed-effect model. RESULTS: The main analysis included 9440, 
      7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting 
      glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. 
      IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 
      mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and 
      BMI or interleukin-6 levels, except in some subgroups. CONCLUSIONS: Our data 
      suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting 
      glucose levels on average, which substantiates previous findings of decreased 
      T2DM risk of these subjects.
FAU - Huth, Cornelia
AU  - Huth C
AD  - Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany.
FAU - Illig, Thomas
AU  - Illig T
FAU - Herder, Christian
AU  - Herder C
FAU - Gieger, Christian
AU  - Gieger C
FAU - Grallert, Harald
AU  - Grallert H
FAU - Vollmert, Caren
AU  - Vollmert C
FAU - Rathmann, Wolfgang
AU  - Rathmann W
FAU - Hamid, Yasmin H
AU  - Hamid YH
FAU - Pedersen, Oluf
AU  - Pedersen O
FAU - Hansen, Torben
AU  - Hansen T
FAU - Thorand, Barbara
AU  - Thorand B
FAU - Meisinger, Christa
AU  - Meisinger C
FAU - Doring, Angela
AU  - Doring A
FAU - Klopp, Norman
AU  - Klopp N
FAU - Gohlke, Henning
AU  - Gohlke H
FAU - Lieb, Wolfgang
AU  - Lieb W
FAU - Hengstenberg, Christian
AU  - Hengstenberg C
FAU - Lyssenko, Valeriya
AU  - Lyssenko V
FAU - Groop, Leif
AU  - Groop L
FAU - Ireland, Helen
AU  - Ireland H
FAU - Stephens, Jeffrey W
AU  - Stephens JW
FAU - Wernstedt Asterholm, Ingrid
AU  - Wernstedt Asterholm I
FAU - Jansson, John-Olov
AU  - Jansson JO
FAU - Boeing, Heiner
AU  - Boeing H
FAU - Mohlig, Matthias
AU  - Mohlig M
FAU - Stringham, Heather M
AU  - Stringham HM
FAU - Boehnke, Michael
AU  - Boehnke M
FAU - Tuomilehto, Jaakko
AU  - Tuomilehto J
FAU - Fernandez-Real, Jose-Manuel
AU  - Fernandez-Real JM
FAU - Lopez-Bermejo, Abel
AU  - Lopez-Bermejo A
FAU - Gallart, Luis
AU  - Gallart L
FAU - Vendrell, Joan
AU  - Vendrell J
FAU - Humphries, Steve E
AU  - Humphries SE
FAU - Kronenberg, Florian
AU  - Kronenberg F
FAU - Wichmann, H-Erich
AU  - Wichmann HE
FAU - Heid, Iris M
AU  - Heid IM
LA  - eng
GR  - RG/08/008/25291/BHF_/British Heart Foundation/United Kingdom
GR  - U01 DK062370/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*genetics/physiopathology
MH  - Humans
MH  - Interleukin-6/blood/*genetics
MH  - Molecular Epidemiology
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
PMC - PMC3801210
MID - NIHMS491628
EDAT- 2008/08/30 09:00
MHDA- 2009/04/29 09:00
PMCR- 2013/10/21
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2013/10/21 00:00 [pmc-release]
AID - 901960407 [pii]
AID - 10.1080/07853890802337037 [doi]
PST - ppublish
SO  - Ann Med. 2009;41(2):128-38. doi: 10.1080/07853890802337037.