PMID- 18752503
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20220408
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 53
IP  - 2
DP  - 2008 Aug
TI  - MYC translocation and an increased copy number predict poor prognosis in adult 
      diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell 
      (GCB) type.
PG  - 205-17
LID - 10.1111/j.1365-2559.2008.03076.x [doi]
AB  - AIMS: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with 
      various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 
      translocations and copy number changes in adult DLBCLs to evaluate their 
      clinicopathological features and prognostic implications. METHODS AND RESULTS: 
      Gene status was examined using fluorescence in situ hybridization (FISH), and the 
      results were analysed in the context of germinal centre B-cell (GCB) and non-GCB 
      type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% 
      (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC 
      translocation was more common in GCB type (22%) than in non-GCB type (4.9%), and 
      associated with advanced International Prognostic Index (IPI). MYC aberration, 
      i.e. translocation or increased copy number (ICN), was significantly associated 
      with shorter overall survival, especially for the GCB type. Bcl-2 translocation 
      was rare (3.4%, five of 145), and ICN was observed in 11.7% (17 of 145), more 
      frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended 
      to have an adverse effect on survival. In multivariate analysis, MYC ICN was an 
      independent poor prognostic factor. CONCLUSIONS: Analyses of MYC and Bcl-2 
      status, i.e. translocation and ICN, in the context of DLBCL phenotype might help 
      predict prognosis and determine therapeutic strategies.
FAU - Yoon, S O
AU  - Yoon SO
AD  - Department of Pathology, Tumour Immunity Medical Research Centre, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Jeon, Y K
AU  - Jeon YK
FAU - Paik, J H
AU  - Paik JH
FAU - Kim, W Y
AU  - Kim WY
FAU - Kim, Y A
AU  - Kim YA
FAU - Kim, J E
AU  - Kim JE
FAU - Kim, C W
AU  - Kim CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - B-Lymphocytes/pathology
MH  - Female
MH  - *Gene Dosage
MH  - Germinal Center/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis/*genetics/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Proto-Oncogene Proteins c-bcl-6/genetics
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - *Translocation, Genetic
EDAT- 2008/08/30 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - HIS3076 [pii]
AID - 10.1111/j.1365-2559.2008.03076.x [doi]
PST - ppublish
SO  - Histopathology. 2008 Aug;53(2):205-17. doi: 10.1111/j.1365-2559.2008.03076.x.