PMID- 18752645
OWN - NLM
STAT- MEDLINE
DCOM- 20081224
LR  - 20181201
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 107
IP  - 2
DP  - 2008 Oct
TI  - Age-dependent effects of chronic stress on brain plasticity and depressive 
      behavior.
PG  - 522-32
LID - 10.1111/j.1471-4159.2008.05642.x [doi]
AB  - Exposure to chronic mild stress (CMS) is known to induce anhedonia in adult 
      animals, and is associated with induction of depression in humans. However, the 
      behavioral effects of CMS in young animals have not yet been characterized, and 
      little is known about the long-term neurochemical effects of CMS in either young 
      or adult animals. Here, we found that CMS induces anhedonia in adult but not in 
      young animals, as measured by a set of behavioral paradigms. Furthermore, while 
      CMS decreased neurogenesis and levels of brain-derived neurotrophic factor (BDNF) 
      in the hippocampus of adult animals, it increased these parameters in young 
      animals. We also found that CMS altered 
      alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor GluR1 
      subunit levels in the hippocampus and the nucleus accumbens of adult, but not 
      young animals. Finally, no significant differences were observed between the 
      effects of CMS on circadian corticosterone levels in the different age groups. 
      The substantially different neurochemical effects chronic stress exerts in young 
      and adult animals may explain the behavioral resilience to such stress young 
      animals possess.
FAU - Toth, Erika
AU  - Toth E
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Gersner, Roman
AU  - Gersner R
FAU - Wilf-Yarkoni, Adi
AU  - Wilf-Yarkoni A
FAU - Raizel, Hagit
AU  - Raizel H
FAU - Dar, Dalit E
AU  - Dar DE
FAU - Richter-Levin, Gal
AU  - Richter-Levin G
FAU - Levit, Ofir
AU  - Levit O
FAU - Zangen, Abraham
AU  - Zangen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080822
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - 57-50-1 (Sucrose)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Aging
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/physiology
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Depression/*etiology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/physiology
MH  - Food Preferences/physiology
MH  - Locomotion/physiology
MH  - Male
MH  - Neurogenesis/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/metabolism
MH  - Stress, Psychological/*complications/*pathology
MH  - Sucrose/administration & dosage
MH  - Swimming
EDAT- 2008/08/30 09:00
MHDA- 2008/12/25 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/12/25 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - JNC5642 [pii]
AID - 10.1111/j.1471-4159.2008.05642.x [doi]
PST - ppublish
SO  - J Neurochem. 2008 Oct;107(2):522-32. doi: 10.1111/j.1471-4159.2008.05642.x. Epub 
      2008 Aug 22.