PMID- 18752728
OWN - NLM
STAT- MEDLINE
DCOM- 20090831
LR  - 20220409
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 39
IP  - 6
DP  - 2009 Jun
TI  - Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and 
      recovered anorexia nervosa (AN) patients.
PG  - 1029-35
LID - 10.1017/S0033291708004108 [doi]
AB  - BACKGROUND: Studies of patients with anorexia nervosa (AN) have shown that they 
      do not perform well in set-shifting tasks but little is known about the 
      neurobiological correlates of this aspect of executive function. The aim of this 
      study was to measure serum brain-derived neurotrophic factor (BDNF) and to 
      establish whether set-shifting difficulties are present in people with current AN 
      and in those recovered from AN, and whether serum BDNF concentrations are 
      correlated with set-shifting ability. METHOD: Serum BDNF concentrations were 
      measured in 29 women with current AN (AN group), 18 women who had recovered from 
      AN (ANRec group) and 28 age-matched healthy controls (HC group). Set-shifting was 
      measured using the Wisconsin Card Sorting Test (WCST). Eating-related 
      psychopathology and depressive, anxiety and obsessive-compulsive symptomatology 
      were evaluated using the Eating Disorder Examination Questionnaire (EDEQ), the 
      Hospital Anxiety and Depression Scale (HADS), and the Maudsley 
      Obsessive-Compulsive Inventory (MOCI) respectively. RESULTS: Serum BDNF 
      concentrations (mean+/-s.d.) were significantly lower in the AN group (11.7+/-4.9 
      ng/ml) compared to the HC group (15.1+/-5.5 ng/ml, p=0.04) and also compared to 
      the ANRec group (17.6+/-4.8 ng/ml, p=0.001). The AN group made significantly more 
      errors (total and perseverative) in the WCST relative to the HC group. There was 
      no significant correlation between serum BDNF concentrations and performance on 
      the WCST. CONCLUSIONS: Serum BDNF may be a biological marker for eating-related 
      psychopathology and of recovery in AN. Longitudinal studies are needed to explore 
      possible associations between serum BDNF concentrations, illness and recovery and 
      neuropsychological traits.
FAU - Nakazato, M
AU  - Nakazato M
AD  - Section of Eating Disorders, Institute of Psychiatry, King's College London, 
      London, UK. michiko.nakazato@nifty.ne.jp
FAU - Tchanturia, K
AU  - Tchanturia K
FAU - Schmidt, U
AU  - Schmidt U
FAU - Campbell, I C
AU  - Campbell IC
FAU - Treasure, J
AU  - Treasure J
FAU - Collier, D A
AU  - Collier DA
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Iyo, M
AU  - Iyo M
LA  - eng
PT  - Journal Article
DEP - 20080828
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Anorexia Nervosa/*blood/psychology/rehabilitation
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Recovery of Function
MH  - Young Adult
EDAT- 2008/08/30 09:00
MHDA- 2009/09/01 06:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/09/01 06:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - S0033291708004108 [pii]
AID - 10.1017/S0033291708004108 [doi]
PST - ppublish
SO  - Psychol Med. 2009 Jun;39(6):1029-35. doi: 10.1017/S0033291708004108. Epub 2008 
      Aug 28.