PMID- 18752793
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20161031
IS  - 0003-4266 (Print)
IS  - 0003-4266 (Linking)
VI  - 69
IP  - 5
DP  - 2008 Nov
TI  - Menin regulates endocrine diseases by controlling histone modification and gene 
      transcription.
PG  - 426-32
LID - 10.1016/j.ando.2008.06.001 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1), a human familial tumor syndrome, 
      results from mutations in the Men1 gene. Although much progress has been made in 
      demonstrating the definitive role for menin in suppressing tumorigenesis in 
      endocrine organs, the molecular pathways responsible for menin action in normal 
      tissues and tumors remain poorly defined. Here, we review the recent progress on 
      the molecular functions of menin in controlling cell proliferation, apoptosis, 
      and DNA repair. The majority of these functions are largely executed by 
      menin-mediated influencing of histone modifications and chromatin structure. 
      These findings lead to a new model of understanding menin's tumor-suppressing 
      function, providing insights into understanding of how menin regulates cell 
      proliferation and the development of endocrine tumors. The new knowledge could 
      also be translated into new strategies to improve therapeutic interventions 
      against MEN1 and other endocrine diseases including diabetes.
FAU - Gao, S B
AU  - Gao SB
AD  - Department of Basic Medical Sciences, Xiamen University Medical College, No. 168, 
      Daxue Road, Xiamen 361005, Fujian Province, PR China.
FAU - Hua, X
AU  - Hua X
FAU - Jin, G H
AU  - Jin GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080826
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (Histones)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - DNA Repair/genetics
MH  - Endocrine Gland Neoplasms/genetics/physiopathology
MH  - Endocrine System Diseases/*genetics/*physiopathology
MH  - Histones/*genetics/*metabolism
MH  - Humans
MH  - Mutation/genetics/physiology
MH  - Protein Processing, Post-Translational/genetics/physiology
MH  - Proto-Oncogene Proteins/*genetics/*physiology
MH  - Transcription, Genetic/*genetics/*physiology
RF  - 60
EDAT- 2008/08/30 09:00
MHDA- 2009/02/25 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - S0003-4266(08)00135-2 [pii]
AID - 10.1016/j.ando.2008.06.001 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2008 Nov;69(5):426-32. doi: 10.1016/j.ando.2008.06.001. 
      Epub 2008 Aug 26.