PMID- 18753062
OWN - NLM
STAT- MEDLINE
DCOM- 20090331
LR  - 20201209
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 28
IP  - 8
DP  - 2008 Aug
TI  - [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and 
      vulnerability to coronary heart disease in patients with type 2 diabetes 
      mellitus].
PG  - 1365-8
AB  - OBJECTIVE: To investigate the association of angiotensin-converting enzyme 2 
      (ACE2) gene polymorphisms and coronary artery disease (CAD) in patients with type 
      2 diabetes mellitus (T2DM). METHODS: This study involved 121 patients with T2DM 
      and 94 with diabetic macroangiopathy. The polymorphisms of G8790A in ACE2 gene 
      was analyzed using PCR-restriction fragment length polymorphism analysis in these 
      patients, and the clinical, biochemical and echocardiographic data were also 
      analyzed. RESULTS: No obvious difference was found in the genotyping data between 
      the two groups. Among the male patients with diabetic macroangiopathy, the 
      interventricular septal end-diastolic thickness (IVSTd) were significantly 
      greater in patients of GG genotypes of ACE2 gene G8790A than in those of AA 
      genotypes (P<0.01), and the left ventricular mass (LVMI) and urine protein were 
      also significantly higher in GG genotypes (P<0.05). No similar results were found 
      the uncomplicated diabetic group or the female diabetic patients with CAD. 
      CONCLUSION: The ACE2 gene G8790A polymorphism plays a role in the pathogenesis of 
      CAD in patients with type 2 diabetes, suggesting that ACE2 genotyping is helpful 
      to screen the susceptible patients.
FAU - Yan, Quan-nang
AU  - Yan QN
AD  - Department of Cardiology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Xu, Chun-sheng
AU  - Xu CS
FAU - Li, Zhi-liang
AU  - Li ZL
FAU - Zhou, Peng
AU  - Zhou P
FAU - Ye, Ren-qing
AU  - Ye RQ
FAU - Li, Ming
AU  - Li M
FAU - Jiang, Chao-xin
AU  - Jiang CX
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - EC 3.4.17.23 (ACE2 protein, human)
RN  - EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Angiotensin-Converting Enzyme 2
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Coronary Disease/complications/*genetics
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
MH  - Sequence Analysis, DNA
EDAT- 2008/08/30 09:00
MHDA- 2009/04/01 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/04/01 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1365-8.