PMID- 18754370
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20190715
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 42
IP  - 14
DP  - 2008 Jul 15
TI  - Screening chemicals for the potential to be persistent organic pollutants: a case 
      study of Arctic contaminants.
PG  - 5202-9
AB  - A large and ever-increasing number of chemicals are used in commerce, and 
      researchers and regulators have struggled to ascertain that these chemicals do 
      not threaten human health or cause environmental or ecological damage. The 
      presence of persistent organic pollutants (POPs) in remote environments such as 
      the Arctic is of special concern and has international regulatory implications. 
      Responding to the need for a way to identify chemicals of high concern, a 
      methodology has been developed which compares experimentally measured properties, 
      or values predicted from chemical structure alone, to a set of screening 
      criteria. These criteria include partitioning properties that allow for 
      accumulation in the physical Arctic environment and in the Arctic human food 
      chain, and resistance to atmospheric oxidation. Atthe same time we quantify the 
      extent of structural resemblance to a group of known Arctic contaminants. 
      Comparison of the substances that are identified by a mechanistic description of 
      the processes that lead to Arctic contamination with those substances that are 
      structurally similar to known Arctic contaminants reveals the strengths and 
      limitations of either approach. Within a data set of more than 100,000 distinct 
      industrial chemicals, the methodology identifies 120 high production volume 
      chemicals which are structurally similarto known Arctic contaminants and/or have 
      partitioning properties that suggest they are potential Arctic contaminants.
FAU - Brown, Trevor N
AU  - Brown TN
AD  - Department of Chemistry, University of Toronto Scarborough, 1265 Military Trail, 
      Toronto, Ontario, Canada M1C 1A4.
FAU - Wania, Frank
AU  - Wania F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
CIN - Environ Sci Technol. 2008 Jul 15;42(14):5034. PMID: 18754340
MH  - Animals
MH  - Arctic Regions
MH  - Environmental Pollutants/*analysis
MH  - Food Chain
MH  - Humans
MH  - Organic Chemicals/*analysis
MH  - Risk Assessment
EDAT- 2008/08/30 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - 10.1021/es8004514 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2008 Jul 15;42(14):5202-9. doi: 10.1021/es8004514.