PMID- 18754697
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20211020
IS  - 1174-5878 (Print)
IS  - 1174-5878 (Linking)
VI  - 10
IP  - 5
DP  - 2008
TI  - Current management of tuberous sclerosis complex.
PG  - 299-313
AB  - Tuberous sclerosis complex (TSC) is an important cause of epilepsy, autism, and 
      renal and pulmonary disease in children and adults. The clinical course of TSC 
      and the prognosis and appropriate therapy for TSC patients are often different 
      than that for individuals with epilepsy, renal tumors, or interstitial lung 
      disease from other causes. This article reviews the current therapeutic 
      recommendations for medical and surgical management of neurologic, renal, and 
      pulmonary manifestations of TSC. In addition, recent clinical trials using 
      inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated 
      regression of astrocytomas, angiofibromas, and angiomyoliomas, as well as 
      improved pulmonary function in persons with TSC.
FAU - Krueger, Darcy A
AU  - Krueger DA
AD  - Tuberous Sclerosis Clinic, University of Cincinnati College of Medicine, 
      Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
FAU - Franz, David N
AU  - Franz DN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Paediatr Drugs
JT  - Paediatric drugs
JID - 100883685
RN  - 0 (Antibiotics, Antineoplastic)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Antibiotics, Antineoplastic/therapeutic use
MH  - Child
MH  - Humans
MH  - Kidney Diseases/drug therapy/etiology
MH  - Lung Diseases/drug therapy/etiology
MH  - Nervous System Diseases/drug therapy/etiology
MH  - Sirolimus/therapeutic use
MH  - Tuberous Sclerosis/*complications/*therapy
RF  - 123
EDAT- 2008/08/30 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - 1054 [pii]
AID - 10.2165/00148581-200810050-00004 [doi]
PST - ppublish
SO  - Paediatr Drugs. 2008;10(5):299-313. doi: 10.2165/00148581-200810050-00004.