PMID- 18754938
OWN - NLM
STAT- MEDLINE
DCOM- 20090106
LR  - 20161124
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 25
IP  - 7
DP  - 2008 Aug
TI  - Effect of alcohol-induced septal ablation on left atrial volume and ejection 
      fraction assessed by real time three-dimensional transthoracic echocardiography 
      in patients with hypertrophic cardiomyopathy.
PG  - 784-9
LID - 10.1111/j.1540-8175.2008.00735.x [doi]
AB  - Alcohol-induced septal ablation (AISA) is an accepted treatment for hypertrophic 
      cardiomyopathy (HCM) patients with left ventricular (LV) outflow obstruction who 
      are unresponsive to medical therapy. As left atrial (LA) enlargement has been 
      correlated with increased morbidity and mortality in HCM, we assessed LA volumes 
      and ejection fraction (EF) prior to and after AISA using real time 
      three-dimensional (3D) transthoracic echocardiography (TTE) in 12 patients (9 
      women; mean age 52 +/- 15 years; 11 Caucasian). All patients underwent successful 
      AISA with no complications and their resting left ventricular outflow gradients 
      decreased from 40.5 +/- 22.2 to 9.1 +/- 17.6 mmHg (P < 0.001) while their 
      gradients with provocation decreased from 126.2 +/- 31.7 to 21.8 +/- 28.0 mmHg (P 
      < 0.001). All patients showed improvements in their New York Heart Association 
      (NYHA) functional class. Both the LA end-systolic (45.2 +/- 12.9 to 37.2 +/- 13.7 
      ml, P < 0.0001) and end-diastolic (79.6 +/- 18.9 to 77.1 +/- 18.6 ml, P = 0.001) 
      volumes decreased after AISA. The LA EF increased from 43.1 +/- 9.0 to 52.5 +/- 
      8.8% (P = 0.001). The increase in LA EF correlated with the decrease in the 
      resting left ventricular outflow gradient (R =-0.647, P = 0.03). In conclusion, 
      3D echocardiography can be utilized to follow LA function after AISA for HCM. 
      AISA results in clinical improvement in patients with HCM and in improvement of 
      LA EF that is correlated with the decrease in the left ventricular outflow 
      gradient.
FAU - Hage, Fadi G
AU  - Hage FG
AD  - Division of Cardiovascular Disease, Department of Medicine, University of Alabama 
      at Birmingham, Birmingham, Alabama 35294-0007, USA.
FAU - Karakus, Gultekin
AU  - Karakus G
FAU - Luke, William D Jr
AU  - Luke WD Jr
FAU - Suwanjutah, Thouantosaporn
AU  - Suwanjutah T
FAU - Burri, Manjula V
AU  - Burri MV
FAU - Nanda, Navin C
AU  - Nanda NC
FAU - Aqel, Raed A
AU  - Aqel RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
RN  - 3K9958V90M (Ethanol)
SB  - IM
EIN - Echocardiography. 2008 Oct;25(9):ii. Burri, Manjula V [added]
MH  - Adult
MH  - Aged
MH  - Cardiac Catheterization
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/mortality/*therapy
MH  - Cohort Studies
MH  - Echocardiography, Three-Dimensional/*methods
MH  - *Echocardiography, Transesophageal
MH  - Ethanol/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Function Tests
MH  - Heart Septum/*drug effects
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Probability
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Ventricular Remodeling
EDAT- 2008/08/30 09:00
MHDA- 2009/01/07 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/01/07 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - ECHO735 [pii]
AID - 10.1111/j.1540-8175.2008.00735.x [doi]
PST - ppublish
SO  - Echocardiography. 2008 Aug;25(7):784-9. doi: 10.1111/j.1540-8175.2008.00735.x.