PMID- 1875787
OWN - NLM
STAT- MEDLINE
DCOM- 19910926
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 49
IP  - 11
DP  - 1991
TI  - Endothelin-1-induced nociception.
PG  - PL61-5
AB  - Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine 
      to mice antagonized the abdominal constriction induced by an i.p. injection of 
      endothelin-1 (ET-1; 0.1 mg/kg). The ED50 values (95% confidence intervals) were 
      39.3 (16.5-80.2) ng and 1.5 (0.8-4.9) ng, respectively. The antagonism of 
      ET-1-induced abdominal constriction by morphine was blocked by naloxone (1.0 
      mg/kg, s.c.) or by 24 h pretreatment with beta-funaltrexamine (beta-FNA; 8.84 
      micrograms, i.c.v.). These results demonstrate for the first time that the 
      stimulus resulting from an i.p. injection of ET-1 is transmitted via ascending 
      (pain) pathways that are subject to attenuation by opioid (mu) receptor 
      activation. Hence, ET-1-induced abdominal constriction is a new pain model which, 
      given the other pharmacology of ET-1, might represent a unique model with 
      potential specific utility for anginal or other visceral pain.
FAU - Raffa, R B
AU  - Raffa RB
AD  - Drug Discovery Research, R.W. Johnson Pharmaceutical Research Institute, Spring 
      House, PA 19477-0776.
FAU - Schupsky, J J
AU  - Schupsky JJ
FAU - Martinez, R P
AU  - Martinez RP
FAU - Jacoby, H I
AU  - Jacoby HI
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Endothelins)
RN  - 36B82AMQ7N (Naloxone)
RN  - 5S6W795CQM (Naltrexone)
RN  - 72782-05-9 (beta-funaltrexamine)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Endothelins/*pharmacology/therapeutic use
MH  - Male
MH  - Mice
MH  - Morphine/pharmacology
MH  - Naloxone/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Pain/*drug therapy
MH  - *Pain Measurement
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0024-3205(91)90252-7 [pii]
AID - 10.1016/0024-3205(91)90252-7 [doi]
PST - ppublish
SO  - Life Sci. 1991;49(11):PL61-5. doi: 10.1016/0024-3205(91)90252-7.