PMID- 18758004
OWN - NLM
STAT- MEDLINE
DCOM- 20081210
LR  - 20080911
IS  - 0031-9155 (Print)
IS  - 0031-9155 (Linking)
VI  - 53
IP  - 19
DP  - 2008 Oct 7
TI  - A heterogeneous dose distribution in simultaneous integrated boost: the role of 
      the clonogenic cell density on the tumor control probability.
PG  - 5257-73
LID - 10.1088/0031-9155/53/19/001 [doi]
AB  - IMRT with inverse planning allows simultaneous integrated boost strategies that 
      exploit the heterogeneous dose distribution within the planning target volumes 
      (PTVs). In this scenario, the location of cold spots within the target becomes a 
      crucial issue and has to be related to the distribution of the clonogenic cell 
      density (CCD). The main aim of this work is to provide the means to calculate the 
      optimal prescription dose in a relative inhomogeneous dose distribution. To 
      achieve this, the prescription dose has to be assigned to obtain the same tumor 
      control probability (TCP) as the ideal homogeneous distribution, taking into 
      account different CCDs in different PTVs (i.e. visible and subclinical regions). 
      An adapted formulation of the linear-quadratic model, within the F-factor 
      formalism, has been derived to preserve a chosen TCP value for the whole target 
      volume. The F-factor has been investigated to show its potential applications in 
      clinical practice.
FAU - Strigari, L
AU  - Strigari L
AD  - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer 
      Institute, Rome, Italy. strigari@ifo.it
FAU - D'Andrea, M
AU  - D'Andrea M
FAU - Abate, A
AU  - Abate A
FAU - Benassi, M
AU  - Benassi M
LA  - eng
PT  - Journal Article
DEP - 20080829
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - Algorithms
MH  - Clone Cells/*pathology/radiation effects
MH  - Humans
MH  - Neoplasms/*pathology/*radiotherapy
MH  - Probability
MH  - *Radiation Dosage
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Intensity-Modulated
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Time Factors
EDAT- 2008/09/02 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/09/02 09:00
PHST- 2008/09/02 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/02 09:00 [entrez]
AID - S0031-9155(08)83981-4 [pii]
AID - 10.1088/0031-9155/53/19/001 [doi]
PST - ppublish
SO  - Phys Med Biol. 2008 Oct 7;53(19):5257-73. doi: 10.1088/0031-9155/53/19/001. Epub 
      2008 Aug 29.