PMID- 1875943
OWN - NLM
STAT- MEDLINE
DCOM- 19910920
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 11
IP  - 9
DP  - 1991 Sep
TI  - trans activation of nerve growth factor in transgenic mice containing the human 
      T-cell lymphotropic virus type I tax gene.
PG  - 4635-41
AB  - Three lines of transgenic mice containing the human T-cell lymphotropic virus 
      type I (HTLV-I) tax gene develop neurofibromas composed of perineural fibroblasts 
      (S. H. Hinrichs, M. Nerenberg, R. K. Reynolds, G. Khoury, and G. Jay, Science 
      237:1340-1343, 1987; M. Nerenberg, S. H. Hinrichs, R. K. Reynolds, G. Khoury, and 
      G. Jay, Science 237:1324-1327, 1987). Tumors and tumor cell lines derived from 
      these mice produce neurite outgrowth from PC-12 cells and nerve growth factor 
      (NGF), as determined by RNA (Northern) blot analysis and enzyme-linked 
      immunosorbent assays. In vitro cotransfection studies demonstrate that Tax is 
      able to trans activate the NGF promoter in NIH 3T3 fibroblast cells. The major 
      cis-acting tax-responsive element in the NGF promoter (AGGGTGTGACGA) has 92% 
      homology with a tax-responsive element contained within the 21-bp repeats of the 
      HTLV-I long terminal repeat. The receptor for NGF is also expressed in the 
      transgenic tumor cells, suggesting that Tax may activate an autocrine mechanism 
      through the upregulation of NGF.
FAU - Green, J E
AU  - Green JE
AD  - Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 
      21702-1201.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Nerve Growth Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - tax
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - DNA
MH  - DNA Mutational Analysis
MH  - *Genes, pX
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Neurofibroma
MH  - Promoter Regions, Genetic
MH  - *Transcriptional Activation
MH  - Tumor Cells, Cultured
PMC - PMC361349
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
PMCR- 1991/09/01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PHST- 1991/09/01 00:00 [pmc-release]
AID - 10.1128/mcb.11.9.4635-4641.1991 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1991 Sep;11(9):4635-41. doi: 10.1128/mcb.11.9.4635-4641.1991.