PMID- 18760669
OWN - NLM
STAT- MEDLINE
DCOM- 20090211
LR  - 20161124
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 10
IP  - 10
DP  - 2008 Oct
TI  - Quality-adjusted life year weights among elderly patients with heart failure.
PG  - 1033-9
LID - 10.1016/j.ejheart.2008.07.015 [doi]
AB  - BACKGROUND: When assessing health-related quality of life (HRQoL) in elderly 
      patients with heart failure (HF), the process of obtaining quality-adjusted life 
      year (QALY) weights is generally complicated and time-consuming. AIM: To evaluate 
      whether information regarding HRQoL and QALY weights can be derived directly from 
      the established and widely used New York Heart Association (NYHA) functional 
      classification system. METHODS: NYHA functional status was assessed independently 
      both by the individual patients and by the examining cardiologist in 323 elderly 
      patients with symptoms of HF recruited from primary care. HRQoL was evaluated 
      using the SF-36 questionnaire and a time trade-off (TTO) scenario. The TTO 
      technique generates direct QALY weights. RESULTS: Both the TTO technique and 
      SF-36 values demonstrated a statistically significant correlation with NYHA 
      functional status. The TTO values also correlated with all SF-36 dimensions. 
      Increasing impairment was associated with statistically significant drops in both 
      SF-36 values and TTO-based QALY weights. For patients in NYHA classes I-IV the 
      QALY weights were 0.77, 0.68, 0.61, and 0.50, respectively. Thus in elderly 
      patients, symptoms of HF have a major impact on perceived quality of life. 
      CONCLUSION: The results of the present study show that QALY weights, an important 
      instrument in the health economic evaluation of treatment strategies, can be 
      derived directly from NYHA classification in elderly HF patients.
FAU - Alehagen, Urban
AU  - Alehagen U
AD  - Department of Cardiology, Heart Centre, University Hospital of Linkoping, 
      Linkoping, Sweden. Urban.Alehagen@IHS.liu.se
FAU - Rahmqvist, Mikael
AU  - Rahmqvist M
FAU - Paulsson, Thomas
AU  - Paulsson T
FAU - Levin, Lars-Ake
AU  - Levin LA
LA  - eng
PT  - Journal Article
DEP - 20080828
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Health Status Indicators
MH  - Health Surveys
MH  - *Heart Failure/diagnostic imaging/epidemiology/physiopathology
MH  - Humans
MH  - Male
MH  - Psychological Tests
MH  - Psychometrics
MH  - *Quality of Life/psychology
MH  - *Quality-Adjusted Life Years
MH  - Sweden/epidemiology
MH  - Ultrasonography
EDAT- 2008/09/02 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/09/02 09:00
PHST- 2008/01/16 00:00 [received]
PHST- 2008/05/22 00:00 [revised]
PHST- 2008/07/24 00:00 [accepted]
PHST- 2008/09/02 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/09/02 09:00 [entrez]
AID - S1388-9842(08)00361-9 [pii]
AID - 10.1016/j.ejheart.2008.07.015 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2008 Oct;10(10):1033-9. doi: 10.1016/j.ejheart.2008.07.015. 
      Epub 2008 Aug 28.