PMID- 18761049
OWN - NLM
STAT- MEDLINE
DCOM- 20081201
LR  - 20081020
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 46
IP  - 10
DP  - 2008 Oct
TI  - Relevance of integrating agricultural practices in pesticide dietary intake 
      indicator.
PG  - 3240-53
LID - 10.1016/j.fct.2008.08.002 [doi]
AB  - The aim of this study is to develop a new indicator of pesticide dietary intake 
      to screen pesticides to include in monitoring programs. This new indicator called 
      the adjusted TMDI (TMDI_Ad), taking account actual pesticide agricultural uses in 
      France, is more precise than the theoretical maximum dietary intake (TMDI), based 
      on maximum residue levels (MRLs) that is usually used. This new modeling of 
      dietary intake is refined according to actual agricultural pesticide uses on 44 
      raw agricultural commodities (RAC), among the most consumed in France, and the 
      rate of food importation of these RAC. The TMDI_Ad was below the TMDI for 322 
      pesticides (79%). The TMDI was above the ADI, for 46 substances. Although 43 of 
      them had a TMDI_Ad below the TMDI, still 36 had a TMDI_Ad above the ADI, which 
      corresponded to substances with the lowest ADIs. Overall, these results indicate 
      that the TMDI_Ad is a useful tool to plan monitoring programs and to refine 
      dietary exposure, according to actual pesticide uses. However, for very toxic 
      substances, having a very low ADI, such as unauthorized substances, other studies 
      have to be conducted in order to better estimate consumer dietary intakes.
FAU - Menard, Celine
AU  - Menard C
AD  - Office of Scientific Support to the Risk Assessment, French Food Safety Agency 
      (AFSSA), 27-31 avenue du General Leclerc, 94701 MAISONS-ALFORT Cedex, France. 
      c.menard@afssa.fr
FAU - Heraud, Fanny
AU  - Heraud F
FAU - Nougadere, Alexandre
AU  - Nougadere A
FAU - Volatier, Jean-Luc
AU  - Volatier JL
FAU - Leblanc, Jean-Charles
AU  - Leblanc JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080809
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Pesticide Residues)
RN  - 0 (Pesticides)
SB  - IM
MH  - Agriculture/*methods
MH  - *Diet
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Pesticide Residues/*chemistry
MH  - Pesticides/*chemistry/*toxicity
RF  - 40
EDAT- 2008/09/02 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/09/02 09:00
PHST- 2008/04/16 00:00 [received]
PHST- 2008/07/31 00:00 [revised]
PHST- 2008/08/02 00:00 [accepted]
PHST- 2008/09/02 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/02 09:00 [entrez]
AID - S0278-6915(08)00425-0 [pii]
AID - 10.1016/j.fct.2008.08.002 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2008 Oct;46(10):3240-53. doi: 10.1016/j.fct.2008.08.002. Epub 
      2008 Aug 9.