PMID- 18761557
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20111117
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 23
IP  - 11
DP  - 2008 Nov
TI  - Association of human leukocyte antigen polymorphism with outcomes of hepatitis B 
      virus infection.
PG  - 1716-21
LID - 10.1111/j.1440-1746.2008.05482.x [doi]
AB  - BACKGROUND AND AIM: Host genetic and environmental factors are viewed as a common 
      basis of the different outcomes of hepatitis B virus (HBV) infection. Human 
      leukocyte antigen (HLA) plays an important role in immunological reaction to HBV 
      infection. In this study, we aimed to determine the association between HBV 
      infection and HLA-A, B, and DRB1 alleles in northern Iran. METHODS: HLA-A, B, and 
      DRB1 alleles in 33 patients with chronic hepatitis B (CHB) and 31 healthy 
      carriers as the persistent group, and 30 subjects who had spontaneously recovered 
      from HBV infection were analyzed by using the polymerase chain reaction 
      (PCR)-sequence-specific primer (PCR-SSP) technique. RESULTS: The frequency of the 
      HLA-A*33 allele was higher in the persistent group than in the recovered group 
      (10.16% vs 0%, P < 0.008); the frequency of the DRB1*13 allele was lower in the 
      persistent group than in the recovered group (3.13% vs 11.67%, P < 0.03). The 
      frequency of the B*52 allele was higher in CHB patients than healthy carriers 
      (7.58% vs 0%, P < 0.05). The logistic regression model showed that the presence 
      of the HLA-DRB1*13 allele was the significant factor associated with protection 
      against the persistency of HBV. There were significant differences between the 
      HBV recovered group, CHB patients, and healthy carriers regarding age, hepatitis 
      B e antigen, and anti-hepatitis B e positivity. CONCLUSION: HLA-A*33 was closely 
      related with susceptibility to persisting hepatitis B infection, and HLA-DRB1*13 
      was closely related with protection against persisting hepatitis B in an Iranian 
      population. These findings emphasized that the host HLA polymorphism is an 
      important factor in determining the outcome of HBV infection.
FAU - Ramezani, Amitis
AU  - Ramezani A
AD  - Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran. 
      iiccom@iiccom.com
FAU - Hasanjani Roshan, Mohammad Reza
AU  - Hasanjani Roshan MR
FAU - Kalantar, Ebrahim
AU  - Kalantar E
FAU - Eslamifar, Ali
AU  - Eslamifar A
FAU - Banifazl, Mohammad
AU  - Banifazl M
FAU - Taeb, Jaleh
AU  - Taeb J
FAU - Aghakhani, Arezoo
AU  - Aghakhani A
FAU - Gachkar, Latif
AU  - Gachkar L
FAU - Velayati, Ali Akbar
AU  - Velayati AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080828
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carrier State/*immunology
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Hepatitis B, Chronic/*genetics/immunology
MH  - Humans
MH  - Iran
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Remission, Spontaneous
MH  - Risk Assessment
MH  - Young Adult
EDAT- 2008/09/03 09:00
MHDA- 2009/04/10 09:00
CRDT- 2008/09/03 09:00
PHST- 2008/09/03 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
PHST- 2008/09/03 09:00 [entrez]
AID - JGH5482 [pii]
AID - 10.1111/j.1440-1746.2008.05482.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2008 Nov;23(11):1716-21. doi: 
      10.1111/j.1440-1746.2008.05482.x. Epub 2008 Aug 28.