PMID- 18762299
OWN - NLM
STAT- MEDLINE
DCOM- 20081209
LR  - 20090115
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1208
IP  - 1-2
DP  - 2008 Oct 24
TI  - Simultaneous determination of 5-nitroimidazoles and nitrofurans in pork by 
      high-performance liquid chromatography-tandem mass spectrometry.
PG  - 101-8
LID - 10.1016/j.chroma.2008.08.055 [doi]
AB  - A simple and specific method has been developed for the simultaneous 
      determination of four 5-nitroimidazoles and their two corresponding metabolites 
      and four nitrofurans in pork. The sample preparation procedure was based on a 
      simple solvent extraction/derivatization combined with solid-phase extraction 
      (SPE) cleanup. The target compounds were identified and quantitatively determined 
      by high-performance liquid chromatography (HPLC) coupled with electrospray 
      ionization tandem mass spectrometry (ESI/MS/MS) operated in multiple reaction 
      monitoring mode. The overall corrected recoveries ranged between 93 and 106%, 
      with relative standard deviations (RSDs) of 7-13% for the entire procedure. The 
      detection limits of the method for the 10 compounds under study ranged from 0.01 
      to 0.2microg/kg.
FAU - Xia, Xi
AU  - Xia X
AD  - Department of Pharmacology and Toxicology, College of Veterinary Medicine, China 
      Agricultural University, National Reference Laboratory for Residues of Veterinary 
      Drugs, Beijing 100094, China.
FAU - Li, Xiaowei
AU  - Li X
FAU - Zhang, Suxia
AU  - Zhang S
FAU - Ding, Shuangyang
AU  - Ding S
FAU - Jiang, Haiyang
AU  - Jiang H
FAU - Li, Jiancheng
AU  - Li J
FAU - Shen, Jianzhong
AU  - Shen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080820
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Nitrofurans)
RN  - 0 (Nitroimidazoles)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Meat/*analysis
MH  - Nitrofurans/*analysis
MH  - Nitroimidazoles/*analysis
MH  - Swine
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2008/09/03 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/09/03 09:00
PHST- 2008/05/05 00:00 [received]
PHST- 2008/08/11 00:00 [revised]
PHST- 2008/08/18 00:00 [accepted]
PHST- 2008/09/03 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/03 09:00 [entrez]
AID - S0021-9673(08)01416-7 [pii]
AID - 10.1016/j.chroma.2008.08.055 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Oct 24;1208(1-2):101-8. doi: 10.1016/j.chroma.2008.08.055. 
      Epub 2008 Aug 20.