PMID- 18762362
OWN - NLM
STAT- MEDLINE
DCOM- 20090309
LR  - 20171116
IS  - 1090-2147 (Electronic)
IS  - 0278-2626 (Linking)
VI  - 69
IP  - 1
DP  - 2009 Feb
TI  - Anomalous brain dominance and the immune system: do left-handers have specific 
      immunological patterns?
PG  - 188-93
LID - 10.1016/j.bandc.2008.07.008 [doi]
AB  - Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) 
      suggested a correlation between brain laterality and immune disorders. To test 
      whether this hypothesis holds true not only for the frequency of immune diseases 
      and circulating autoantibodies, but extends also to cellular immunity, we 
      examined the association between handedness and markers of cellular immunity. 
      Twenty-seven left-handed and 37 right-handed subjects were serologically screened 
      for cellular parameters and 22 left-handed subjects were typed for human 
      leukocyte antigen (HLA). When compared to the right-handers, the left-handed 
      group showed a significant decrease in the inflammatory cell types CD3(+) T cells 
      (total T cells), CD4(+) T cells (T-helper cells), and HLA-Dr (MHC-II, 
      antigen-presenting cells) as well as in the CD19(+) cells (B cells) and 
      CD16/CD57(+) cells (natural killer cells). We assume a relationship exists 
      between cerebral hemispheric specialisation and the immune system not only for 
      humoral but also for cellular immunity, and we discuss the role of the major 
      histocompatibility complex in neurological and immunological development.
FAU - Lengen, Charis
AU  - Lengen C
AD  - Clinic Schloesslioa AG, Private Psychiatric Hospital, Schloesslistrasse 8, 
      CH-8618 Oetwil am See, Switzerland. charis.lengen@schloessli.ch
FAU - Regard, Marianne
AU  - Regard M
FAU - Joller, Helen
AU  - Joller H
FAU - Landis, Theodor
AU  - Landis T
FAU - Lalive, Patrice
AU  - Lalive P
LA  - eng
PT  - Journal Article
DEP - 20080830
PL  - United States
TA  - Brain Cogn
JT  - Brain and cognition
JID - 8218014
RN  - 0 (CD3 Complex)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - B-Lymphocytes/immunology
MH  - CD3 Complex/metabolism
MH  - CD4-Positive T-Lymphocytes/physiology
MH  - Functional Laterality/*physiology
MH  - HLA Antigens/blood
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - *Immunity, Cellular
MH  - Lymphocyte Count
MH  - Middle Aged
MH  - Natural Killer T-Cells/immunology
MH  - T-Lymphocyte Subsets/immunology
MH  - T-Lymphocytes/immunology/metabolism
MH  - Young Adult
EDAT- 2008/09/03 09:00
MHDA- 2009/03/10 09:00
CRDT- 2008/09/03 09:00
PHST- 2008/02/07 00:00 [received]
PHST- 2008/07/10 00:00 [revised]
PHST- 2008/07/14 00:00 [accepted]
PHST- 2008/09/03 09:00 [pubmed]
PHST- 2009/03/10 09:00 [medline]
PHST- 2008/09/03 09:00 [entrez]
AID - S0278-2626(08)00238-8 [pii]
AID - 10.1016/j.bandc.2008.07.008 [doi]
PST - ppublish
SO  - Brain Cogn. 2009 Feb;69(1):188-93. doi: 10.1016/j.bandc.2008.07.008. Epub 2008 
      Aug 30.