PMID- 18763782
OWN - NLM
STAT- MEDLINE
DCOM- 20081110
LR  - 20240109
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 56
IP  - 18
DP  - 2008 Sep 24
TI  - Metabolic fate of [14C] chlorophenols in radish (Raphanus sativus), lettuce 
      (Lactuca sativa), and spinach (Spinacia oleracea).
PG  - 8461-9
LID - 10.1021/jf8016354 [doi]
AB  - Chlorophenols are potentially harmful pollutants that are found in numerous 
      natural and agricultural systems. Plants are a sink for xenobiotics, which occur 
      either intentionally or not, as they are unable to eliminate them although they 
      generally metabolize them into less toxic compounds. The metabolic fate of [ 
      (14)C] 4-chlorophenol (4-CP), [ (14)C] 2,4-dichlorophenol (2,4-DCP), and [ (14)C] 
      2,4,5-trichlorophenol (2,4,5-TCP) was investigated in lettuce, spinach, and 
      radish to locate putative toxic metabolites that could become bioavailable to 
      food chains. Radish plants were grown on sand for four weeks before roots were 
      dipped in a solution of radiolabeled chlorophenol. The leaves of six-week old 
      lettuce and spinach were treated. Three weeks after treatments, metabolites from 
      edible plant parts were extracted and analyzed by high performance liquid 
      chromatography (HPLC) and characterized by mass spectrometry (MS), and nuclear 
      magnetic resonance spectroscopy (NMR). Characterization of compounds highlighted 
      the presence of complex glycosides. Upon hydrolysis in the digestive tract of 
      animals or humans, these conjugates could return to the toxic parent compound, 
      and this should be kept in mind for registration studies.
FAU - Pascal-Lorber, Sophie
AU  - Pascal-Lorber S
AD  - INRA, UMR1089 Xenobiotiques, 180 ch. de Tournefeuille, BP3, F-31931 Toulouse, 
      Cedex 9, France. spascal@toulouse.inra.fr
FAU - Despoux, Sabrina
AU  - Despoux S
FAU - Rathahao, Estelle
AU  - Rathahao E
FAU - Canlet, Cecile
AU  - Canlet C
FAU - Debrauwer, Laurent
AU  - Debrauwer L
FAU - Laurent, Francois
AU  - Laurent F
LA  - eng
PT  - Journal Article
DEP - 20080903
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Chlorophenols)
RN  - 0 (Environmental Pollutants)
RN  - 32526637PN (2,4,5-trichlorophenol)
RN  - 3DLC36A01X (4-chlorophenol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Carbon Radioisotopes
MH  - Chlorophenols/*metabolism
MH  - Environmental Pollutants/*metabolism
MH  - Lactuca/*metabolism
MH  - Raphanus/*metabolism
MH  - Spinacia oleracea/*metabolism
EDAT- 2008/09/04 09:00
MHDA- 2008/11/11 09:00
CRDT- 2008/09/04 09:00
PHST- 2008/09/04 09:00 [pubmed]
PHST- 2008/11/11 09:00 [medline]
PHST- 2008/09/04 09:00 [entrez]
AID - 10.1021/jf8016354 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2008 Sep 24;56(18):8461-9. doi: 10.1021/jf8016354. Epub 2008 
      Sep 3.