PMID- 18764901
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20151119
IS  - 0031-8655 (Print)
IS  - 0031-8655 (Linking)
VI  - 85
IP  - 1
DP  - 2009 Jan-Feb
TI  - Effect of low intensity helium-neon (HeNe) laser irradiation on experimental 
      paracoccidioidomycotic wound healing dynamics.
PG  - 227-33
LID - 10.1111/j.1751-1097.2008.00423.x [doi]
AB  - The effect of HeNe laser on the extracellular matrix deposition, chemokine 
      expression and angiogenesis in experimental paracoccidioidomycotic lesions was 
      investigated. At days 7, 8 and 9 postinfection the wound of each animal was 
      treated with a 632.8 nm HeNe laser at a dose of 3 J cm(-2). At day 10 
      postinfection, the wounds were examined by using histologic and 
      immunohistochemical methods. Results revealed that laser-treated lesions were 
      lesser extensive than untreated ones, and composed mainly by macrophages and 
      lymphocytes. High IL-1beta expression was shown in the untreated group whereas in 
      laser-treated animals the expression was scarce. On the other hand, the 
      expression of CXCL-10 was found to be reduced in untreated animals and quite 
      intensive and well distributed in the laser-treated ones. Also, untreated lesions 
      presented vascular endothelial growth factor (VEGF) in a small area near the 
      center of the lesion and high immunoreactivity for hypoxia-inducible factor-1 
      (HIF-1), whereas laser-treated lesions expressed VEGF surrounding blood vessels 
      and little immunoreactivity for HIF-1. Laser-treated lesions presented much more 
      reticular fibers and collagen deposition when compared with the untreated lesion. 
      Our results show that laser was efficient in minimizing the local effects 
      observed in paracoccidioidomycosis and can be an efficient tool in the treatment 
      of this infection, accelerating the healing process.
FAU - Ferreira, Maria Carolina
AU  - Ferreira MC
AD  - Department of Microbiology, Institute of Biology, State University at Campinas 
      (UNICAMP), Campinas, SP, Brazil.
FAU - Gameiro, Jacy
AU  - Gameiro J
FAU - Nagib, Patricia Resende Alo
AU  - Nagib PR
FAU - Brito, Vania Nieto
AU  - Brito VN
FAU - Vasconcellos, Elza da Costa Cruz
AU  - Vasconcellos Eda C
FAU - Verinaud, Liana
AU  - Verinaud L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080827
PL  - United States
TA  - Photochem Photobiol
JT  - Photochemistry and photobiology
JID - 0376425
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Cxcl10 protein, mouse)
RN  - 0 (Interleukin-1beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Chemokine CXCL10/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Lasers, Gas/*therapeutic use
MH  - *Low-Level Light Therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Paracoccidioidomycosis/metabolism/pathology/*radiotherapy
MH  - Wound Healing/*radiation effects
EDAT- 2008/09/04 09:00
MHDA- 2009/04/11 09:00
CRDT- 2008/09/04 09:00
PHST- 2008/09/04 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
PHST- 2008/09/04 09:00 [entrez]
AID - PHP423 [pii]
AID - 10.1111/j.1751-1097.2008.00423.x [doi]
PST - ppublish
SO  - Photochem Photobiol. 2009 Jan-Feb;85(1):227-33. doi: 
      10.1111/j.1751-1097.2008.00423.x. Epub 2008 Aug 27.