PMID- 18765192
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20080903
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 27
IP  - 9
DP  - 2008 Sep
TI  - The killer immunoglobulin-like receptor (KIR) group A haplotype is associated 
      with bronchiolitis obliterans syndrome after lung transplantation.
PG  - 995-1001
LID - 10.1016/j.healun.2008.06.006 [doi]
AB  - BACKGROUND: The development of bronchiolitis obliterans syndrome (BOS) after lung 
      transplantation is associated with viral infections. Natural killer (NK) cells 
      are involved in the lysis of viral infected cells, and their activation is 
      largely controlled by activating and inhibitory killer immunoglobulin-like 
      receptors (KIRs). We hypothesized that KIR ligand incompatibility and recipients' 
      individual KIRs could influence the development of BOS and the incidence of 
      cytomegalovirus reactivation after lung transplantation. METHODS: The KIR gene 
      contents were determined in 48 patients who received a lung transplant, and human 
      leukocyte antigen (HLA)-Cw and HLA-Bw4 typing was performed on their respective 
      donors. RESULTS: BOS developed in 7 patients and cytomegalovirus reactivation 
      occurred in 16. BOS developed in 5 of 19 patients homozygous for KIR haplotype A 
      compared with 2 of 27 patients with KIR haplotype AB and B (homozygous; p = 0.03; 
      log-rank test). In none of the patients with BOS was the activating KIR2DS5 gene 
      detected, whereas it was present in 35% of patients without BOS (p = 0.04; 
      log-rank test). No correlation was found between KIR gene content and 
      cytomegalovirus reactivation. CONCLUSION: Our results suggest that the lack of 
      activating KIRs may play an important role in the development of BOS but not in 
      the control of cytomegalovirus reactivation after lung transplantation.
FAU - Kwakkel-van Erp, Johanna M
AU  - Kwakkel-van Erp JM
AD  - Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - van de Graaf, Ed A
AU  - van de Graaf EA
FAU - Paantjens, Annelieke W M
AU  - Paantjens AW
FAU - van Ginkel, Walter G J
AU  - van Ginkel WG
FAU - Schellekens, Jennifer
AU  - Schellekens J
FAU - van Kessel, Diana A
AU  - van Kessel DA
FAU - van den Bosch, Jules M M
AU  - van den Bosch JM
FAU - Otten, Henny G
AU  - Otten HG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (KIR2DS5 protein, human)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Bronchiolitis Obliterans/*epidemiology
MH  - Cytomegalovirus Infections/epidemiology/*immunology
MH  - Drug Therapy, Combination
MH  - Forced Expiratory Volume
MH  - Genotype
MH  - Graft Rejection/*immunology
MH  - Homozygote
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Killer Cells, Natural/*immunology
MH  - Lung Transplantation/*adverse effects/*immunology/physiology
MH  - Polymerase Chain Reaction
MH  - Postoperative Complications/epidemiology/immunology
MH  - Receptors, KIR/*genetics/immunology
MH  - Recurrence
EDAT- 2008/09/04 09:00
MHDA- 2009/02/14 09:00
CRDT- 2008/09/04 09:00
PHST- 2008/02/22 00:00 [received]
PHST- 2008/06/04 00:00 [revised]
PHST- 2008/06/10 00:00 [accepted]
PHST- 2008/09/04 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2008/09/04 09:00 [entrez]
AID - S1053-2498(08)00476-2 [pii]
AID - 10.1016/j.healun.2008.06.006 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2008 Sep;27(9):995-1001. doi: 
      10.1016/j.healun.2008.06.006.