PMID- 18766374
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20211020
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 168
IP  - 6
DP  - 2009 Jun
TI  - Reduced rate of adverse reactions to the BCG vaccine in children exposed to the 
      vertical transmission of HIV infection and in HIV-infected children from an 
      endemic setting in Brazil.
PG  - 691-6
LID - 10.1007/s00431-008-0822-y [doi]
AB  - We report on the adverse reactions to the Bacillus Calmette-Guerin (BCG) vaccine 
      in BCG-vaccinated children. We examined children exposed to the vertical 
      transmission of human immunodeficiency virus (HIV) (n = 141), who participated in 
      a prevention program of vertical transmission, and HIV-infected children (n = 66) 
      in a setting endemic for HIV and tuberculosis (TB) in Brazil from August 2000 to 
      February 2008. No cases of disseminated BCG disease occurred in either group of 
      children. While no cases of regional BCG disease were noted in exposed/uninfected 
      children, the rate of regional BCG disease in HIV-infected children was 4.5% 
      (3/66); the three events occurred in <1-year-old children (3/17; 17.6%). One case 
      was associated with severe immunodepression before highly active antiretroviral 
      therapy (HAART). Two cases were manifestations of immune reconstitution 
      inflammatory syndrome (IRIS). Among the HIV-infected children, the accrued 
      benefits of potentially preventing severe TB outweighed the risks associated with 
      the use of the BCG vaccine.
FAU - Fernandes, Regina Celia de Souza Campos
AU  - Fernandes RC
AD  - Municipal Program for the Surveillance of Sexually Transmitted Diseases and 
      Acquired Immunodeficiency Syndrome of Campos dos Goytacazes, Rua Conselheiro 
      Otaviano 214, Campos dos Goytacazes, RJ, 28010-140, Brazil. 
      reg.fernandes@bol.com.br
FAU - de Araujo, Luciana Cordeiro
AU  - de Araujo LC
FAU - Medina-Acosta, Enrique
AU  - Medina-Acosta E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080903
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (BCG Vaccine)
SB  - IM
MH  - BCG Vaccine/*adverse effects
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Endemic Diseases
MH  - Female
MH  - HIV Infections/epidemiology/prevention & control/*transmission
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical/prevention & control
MH  - Prospective Studies
MH  - Tuberculosis/epidemiology/*prevention & control
EDAT- 2008/09/04 09:00
MHDA- 2009/09/18 06:00
CRDT- 2008/09/04 09:00
PHST- 2008/07/09 00:00 [received]
PHST- 2008/08/13 00:00 [accepted]
PHST- 2008/09/04 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
PHST- 2008/09/04 09:00 [entrez]
AID - 10.1007/s00431-008-0822-y [doi]
PST - ppublish
SO  - Eur J Pediatr. 2009 Jun;168(6):691-6. doi: 10.1007/s00431-008-0822-y. Epub 2008 
      Sep 3.