PMID- 18768207
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20131121
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 73
IP  - 6
DP  - 2008 Oct
TI  - Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood 
      collected from 127 elderly residents in Nakagawa Town, Fukuoka Prefecture, Japan.
PG  - 865-72
LID - 10.1016/j.chemosphere.2008.07.058 [doi]
AB  - We conducted congener-specific analysis of non-dioxin-like polychlorinated 
      biphenyls (non-dioxin-like PCBs) in blood collected in February 2004 from 127 
      elderly residents living in Nakagawa Town, Fukuoka Prefecture, Japan. The present 
      study is one of the few studies in which 56 non-dioxin-like PCBs congeners were 
      measured in human blood. Of the 127 elderly residents, 51 were men (mean: 68.1 
      years) and 76 were women (mean: 68.1 years). Among 197 non-dioxin-like PCB 
      congeners, 56 were identified in the blood of elderly residents. The arithmetic 
      mean total concentrations of 56 non-dioxin-like PCBs congeners in the blood of 
      elderly men and women in Nakagawa Town were 419 (median: 378) and 363 (median: 
      323)ngg(-1)lipid, respectively, and the concentrations were in the range of 
      172-1102 and 119-1226ngg(-1)lipid, respectively, indicating that the total 
      concentrations in elderly men are significantly higher than those in elderly 
      women. The contamination of non-dioxin-like PCBs in the blood of elderly men and 
      women in Fukuoka Prefecture was found to have decreased compared to past levels. 
      The ratios of hexachlorinated biphenyls (hexaCBs) to the total concentrations of 
      56 non-dioxin-like PCBs congeners in the blood of elderly men and women were 
      44.6% and 45.6%, respectively, which was particularly high compared with those of 
      other congeners. 2,2',4,4',5,5'-HexaCB (#153) among hexaCBs congeners, the most 
      abundant congener in the blood of elderly men and women, contributed 
      approximately 23.0% and 23.5% to the total concentrations of 56 non-dioxin-like 
      PCBs congeners, respectively. Furthermore, 2,2',3,4,4',5'-hexaCB (#138), 
      2,3,3',4',5,6-hexaCB (#163)/2,3,3',4',5',6-hexaCB (#164), 
      2,2',3,4,4',5,5'-heptaCB (#180), and 2,2',3,4,4',5,6'-heptaCB 
      (#182)/2,2',3,4',5,5',6-heptaCB (#187) also showed high ratios to the total 
      concentrations of 56 non-dioxin-like PCBs congeners detected in the blood of 
      elderly men and women. A statistical examination of the relationship between the 
      total concentrations of 56 non-dioxin-like PCBs congeners in blood and the age of 
      elderly residents who were over 60 years indicated statistically significant 
      correlations between the total concentrations of these PCBs congeners and the age 
      of elderly women. However, similar correlations were not observed in elderly men. 
      The results of the present study have indicated the current levels of 
      non-dioxin-like PCBs in the blood of elderly men and women in Fukuoka Prefecture, 
      Japan and can be used as baseline data for those over age 60.
FAU - Todaka, Takashi
AU  - Todaka T
AD  - Department of Dermatology, Graduate School of Medical Sciences, Kyushu 
      University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. 
      todaka@fihes.pref.fukuoka.jp
FAU - Hori, Tsuguhide
AU  - Hori T
FAU - Hirakawa, Hironori
AU  - Hirakawa H
FAU - Kajiwara, Jumboku
AU  - Kajiwara J
FAU - Yasutake, Daisuke
AU  - Yasutake D
FAU - Onozuka, Daisuke
AU  - Onozuka D
FAU - Iida, Takao
AU  - Iida T
FAU - Furue, Masutaka
AU  - Furue M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080902
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Environmental Pollutants/*blood/*chemistry
MH  - Female
MH  - Humans
MH  - Japan
MH  - Lipids/blood
MH  - Male
MH  - Polychlorinated Biphenyls/*blood/*chemistry
EDAT- 2008/09/05 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/09/05 09:00
PHST- 2008/02/23 00:00 [received]
PHST- 2008/07/19 00:00 [revised]
PHST- 2008/07/21 00:00 [accepted]
PHST- 2008/09/05 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/09/05 09:00 [entrez]
AID - S0045-6535(08)00959-4 [pii]
AID - 10.1016/j.chemosphere.2008.07.058 [doi]
PST - ppublish
SO  - Chemosphere. 2008 Oct;73(6):865-72. doi: 10.1016/j.chemosphere.2008.07.058. Epub 
      2008 Sep 2.