PMID- 18769865
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20111117
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 45
IP  - 4
DP  - 2008 Dec
TI  - Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden 
      from 1986 to 2005 suggest altered risk.
PG  - 231-5
LID - 10.1007/s00592-008-0048-5 [doi]
AB  - The aim of this study was to compare the frequency of human leukocyte antigen 
      (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 
      1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested 
      the hypothesis that the HLA DQ genotype distribution changes over time. Swedish 
      type 1 diabetes patients and controls were typed for HLA using polymerase chain 
      reaction amplification and allele specific probes for DQ A1* and B1* alleles. The 
      most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% 
      (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% 
      (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased 
      from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 
      0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the 
      notion that there is a temporal change in HLA risk.
FAU - Resic-Lindehammer, Sabina
AU  - Resic-Lindehammer S
AD  - Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University 
      Hospital MAS, CRC/Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden. 
      sabina.lindehammer@med.lu.se
FAU - Larsson, K
AU  - Larsson K
FAU - Ortqvist, E
AU  - Ortqvist E
FAU - Carlsson, A
AU  - Carlsson A
FAU - Cederwall, E
AU  - Cederwall E
FAU - Cilio, C M
AU  - Cilio CM
FAU - Ivarsson, S-A
AU  - Ivarsson SA
FAU - Jonsson, B A
AU  - Jonsson BA
FAU - Larsson, H E
AU  - Larsson HE
FAU - Lynch, K
AU  - Lynch K
FAU - Neiderud, J
AU  - Neiderud J
FAU - Nilsson, A
AU  - Nilsson A
FAU - Sjoblad, S
AU  - Sjoblad S
FAU - Lernmark, A
AU  - Lernmark A
CN  - Swedish Childhood Diabetes Study Group
FAU - Aili, M
AU  - Aili M
FAU - Baath, L E
AU  - Baath LE
FAU - Carlsson, E
AU  - Carlsson E
FAU - Edenwall, H
AU  - Edenwall H
FAU - Forsander, G
AU  - Forsander G
FAU - Granstro, B W
AU  - Granstro BW
FAU - Gustavsson, I
AU  - Gustavsson I
FAU - Hanas, R
AU  - Hanas R
FAU - Hellenberg, L
AU  - Hellenberg L
FAU - Hellgren, H
AU  - Hellgren H
FAU - Holmberg, E
AU  - Holmberg E
FAU - Hornell, H
AU  - Hornell H
FAU - Ivarsson, Sten-A
AU  - Ivarsson SA
FAU - Johansson, C
AU  - Johansson C
FAU - Jonsell, G
AU  - Jonsell G
FAU - Kockum, K
AU  - Kockum K
FAU - Lindblad, B
AU  - Lindblad B
FAU - Lindh, A
AU  - Lindh A
FAU - Ludvigsson, J
AU  - Ludvigsson J
FAU - Myrdal, U
AU  - Myrdal U
FAU - Neiderud, J
AU  - Neiderud J
FAU - Segnestam, K
AU  - Segnestam K
FAU - Sjoblad, S
AU  - Sjoblad S
FAU - Skogsberg, L
AU  - Skogsberg L
FAU - Stromberg, L
AU  - Stromberg L
FAU - Stahle, U
AU  - Stahle U
FAU - Thalme, B
AU  - Thalme B
FAU - Tullus, K
AU  - Tullus K
FAU - Tuvemo, T
AU  - Tuvemo T
FAU - Wallensteen, M
AU  - Wallensteen M
FAU - Westphal, O
AU  - Westphal O
FAU - Aman, J
AU  - Aman J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20080904
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - *Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Infant
MH  - Male
MH  - Sweden/epidemiology
EDAT- 2008/09/05 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/09/05 09:00
PHST- 2007/12/17 00:00 [received]
PHST- 2008/07/14 00:00 [accepted]
PHST- 2008/09/05 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/09/05 09:00 [entrez]
AID - 10.1007/s00592-008-0048-5 [doi]
PST - ppublish
SO  - Acta Diabetol. 2008 Dec;45(4):231-5. doi: 10.1007/s00592-008-0048-5. Epub 2008 
      Sep 4.