PMID- 18769915
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20211020
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 60
IP  - 11
DP  - 2008 Nov
TI  - The peptide-binding specificity of HLA-A*3001 demonstrates membership of the 
      HLA-A3 supertype.
PG  - 633-43
LID - 10.1007/s00251-008-0317-z [doi]
AB  - Human leukocyte antigen class I (HLA-I) molecules are highly polymorphic peptide 
      receptors, which select and present endogenously derived peptide epitopes to CD8+ 
      cytotoxic T cells (CTL). The specificity of the HLA-I system is an important 
      component of the overall specificity of the CTL immune system. Unfortunately, the 
      large and rapidly increasing number of known HLA-I molecules seriously 
      complicates a comprehensive analysis of the specificities of the entire HLA-I 
      system (as of June 2008, the international HLA registry holds >1,650 unique HLA-I 
      protein entries). In an attempt to reduce this complexity, it has been suggested 
      to cluster the different HLA-I molecules into "supertypes" of largely overlapping 
      peptide-binding specificities. Obviously, the HLA supertype concept is only 
      valuable if membership can be assigned with reasonable accuracy. The supertype 
      assignment of HLA-A*3001, a common HLA haplotype in populations of African 
      descent, has variously been assigned to the A1, A3, or A24 supertypes. Using a 
      biochemical HLA-A*3001 binding assay, and a large panel of nonamer peptides and 
      peptide libraries, we here demonstrate that the specificity of HLA-A*3001 most 
      closely resembles that of the HLA-A3 supertype. We discuss approaches to 
      supertype assignment and underscore the importance of experimental verification.
FAU - Lamberth, Kasper
AU  - Lamberth K
AD  - Laboratory of Experimental Immunology, Faculty of Health Sciences, University of 
      Copenhagen, Panum 18.3.12, Blegdamsvej 3B, 2200, Copenhagen, Denmark. 
      k.lamberth@immi.ku.dk
FAU - Roder, Gustav
AU  - Roder G
FAU - Harndahl, Mikkel
AU  - Harndahl M
FAU - Nielsen, Morten
AU  - Nielsen M
FAU - Lundegaard, Claus
AU  - Lundegaard C
FAU - Schafer-Nielsen, Claus
AU  - Schafer-Nielsen C
FAU - Lund, Ole
AU  - Lund O
FAU - Buus, Soren
AU  - Buus S
LA  - eng
GR  - HHSN266200400025C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080904
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-A Antigens)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptide Library)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Combinatorial Chemistry Techniques
MH  - *Genes, MHC Class I
MH  - HLA-A Antigens/*chemistry/genetics/metabolism
MH  - Humans
MH  - Multigene Family
MH  - Oligopeptides/*metabolism
MH  - Peptide Library
MH  - Phylogeny
MH  - Protein Binding
MH  - Substrate Specificity
EDAT- 2008/09/05 09:00
MHDA- 2009/03/21 09:00
CRDT- 2008/09/05 09:00
PHST- 2008/04/16 00:00 [received]
PHST- 2008/06/23 00:00 [accepted]
PHST- 2008/09/05 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
PHST- 2008/09/05 09:00 [entrez]
AID - 10.1007/s00251-008-0317-z [doi]
PST - ppublish
SO  - Immunogenetics. 2008 Nov;60(11):633-43. doi: 10.1007/s00251-008-0317-z. Epub 2008 
      Sep 4.