PMID- 187711
OWN - NLM
STAT- MEDLINE
DCOM- 19770224
LR  - 20071115
IS  - 0022-0752 (Print)
IS  - 0022-0752 (Linking)
VI  - 36
IP  - 2
DP  - 1976 Oct
TI  - Cell aggregation and sexual differentiation in pairs of aggregation-deficient 
      mutants of Dictyostelium discoideum.
PG  - 431-42
AB  - A diffusible aggregation-stimulating factor (ASF) is released from a series of 
      aggregation-deficient mutants. Biochemical markers indicate that these ASF-donor 
      mutants are blocked at a later step of cell differentiation than an ASF-requiring 
      mutant. ASF is able to bridge the initial block of differentiation in the latter 
      mutant, such that development proceeds up to aggregation and even further. ASF is 
      most probably neither identical with cyclic-AMP phosphodiesterase nor with an 
      inhibitor of this enzyme which both are released from donor strains. In certain 
      combinations of aggregation-deficient mutants, macrocysts, the sexual stages of 
      Dictyostelium, are formed. Also, motile giant cells believed to be zygotes are 
      observed in these mutant combinations. The gamone known to be released from one 
      mating type and to induce macrocysts in the other, is probably not identical with 
      ASF since this factor is produced by mutants derived from either one of both 
      mating types.
FAU - Gerisch, G
AU  - Gerisch G
FAU - Huesgen, A
AU  - Huesgen A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Embryol Exp Morphol
JT  - Journal of embryology and experimental morphology
JID - 7906439
RN  - EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases)
SB  - IM
MH  - 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors
MH  - Animals
MH  - Cell Aggregation
MH  - Cell Differentiation
MH  - Clone Cells
MH  - Dictyostelium/*growth & development
MH  - *Mutation
MH  - Myxomycetes/*growth & development
MH  - Phenotype
MH  - *Sex Differentiation
EDAT- 1976/10/01 00:00
MHDA- 1976/10/01 00:01
CRDT- 1976/10/01 00:00
PHST- 1976/10/01 00:00 [pubmed]
PHST- 1976/10/01 00:01 [medline]
PHST- 1976/10/01 00:00 [entrez]
PST - ppublish
SO  - J Embryol Exp Morphol. 1976 Oct;36(2):431-42.