PMID- 18771751
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20131121
IS  - 1471-4892 (Print)
IS  - 1471-4892 (Linking)
VI  - 8
IP  - 6
DP  - 2008 Dec
TI  - Reflux inhibitors: a new approach for GERD?
PG  - 685-9
LID - 10.1016/j.coph.2008.08.005 [doi]
AB  - A significant proportion of patients on proton pump inhibitors (PPI) reports 
      insufficient control of symptoms, most probably resulting from ongoing reflux of 
      non-acid and acid material. As reflux mainly occurs during transient lower 
      esophageal sphincter relaxations (TLESRs), drugs targeting this motor pattern may 
      be of great interest to further reduce symptoms. Baclofen, a GABA(B) receptor 
      agonist, is the prototype of reflux inhibitors, reducing the number of TLESRs, 
      reflux, and symptoms, but the central side effects are significant. Peripheral 
      acting GABA(B) agonists hopefully devoid of these side effects are currently 
      under study. Alternatively, antagonists to the metabotropic glutamate receptor 5 
      (mGluR5) reported to reduce TLESRs and reflux may be of interest. Upcoming 
      clinical trials with these reflux inhibitors will hopefully answer the question 
      whether reflux inhibitors are indeed a new approach to treat GERD.
FAU - Boeckxstaens, Guy E
AU  - Boeckxstaens GE
AD  - Department of Gastroenterology, University Hospitals Leuven, Catholic University 
      of Leuven, Belgium. guy.boeckxstaens@med.kuleuven.be
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080917
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
RN  - 0 (Muscle Relaxants, Central)
RN  - 0 (Proton Pump Inhibitors)
RN  - H789N3FKE8 (Baclofen)
SB  - IM
MH  - Animals
MH  - Baclofen/pharmacology/therapeutic use
MH  - Esophageal Sphincter, Lower/drug effects/physiopathology
MH  - Esophagitis, Peptic/*drug therapy/physiopathology/prevention & control
MH  - Gastroesophageal Reflux/*drug therapy/physiopathology
MH  - Humans
MH  - Muscle Relaxants, Central/pharmacology/therapeutic use
MH  - Muscle Relaxation/*drug effects
MH  - Proton Pump Inhibitors/pharmacology/therapeutic use
RF  - 50
EDAT- 2008/09/06 09:00
MHDA- 2009/03/20 09:00
CRDT- 2008/09/06 09:00
PHST- 2008/06/27 00:00 [received]
PHST- 2008/08/11 00:00 [revised]
PHST- 2008/08/11 00:00 [accepted]
PHST- 2008/09/06 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/09/06 09:00 [entrez]
AID - S1471-4892(08)00124-0 [pii]
AID - 10.1016/j.coph.2008.08.005 [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2008 Dec;8(6):685-9. doi: 10.1016/j.coph.2008.08.005. Epub 
      2008 Sep 17.