PMID- 18772004
OWN - NLM
STAT- MEDLINE
DCOM- 20081202
LR  - 20240418
IS  - 0065-2776 (Print)
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 98
DP  - 2008
TI  - New insights on mast cell activation via the high affinity receptor for IgE.
PG  - 85-120
LID - 10.1016/S0065-2776(08)00403-3 [doi]
AB  - Mast cells are innate immune cells that function as regulatory or effector cells 
      and serve to amplify adaptive immunity. In adaptive immunity these cells function 
      primarily through cell surface Fc receptors that bind immunoglobulin antibodies. 
      The dysregulation of their adaptive role makes them central players in allergy 
      and asthma. Upon encountering an allergen (antigen), which is recognized by 
      immunoglobulin E (IgE) antibodies bound to the high affinity IgE receptor 
      (FcepsilonRI) expressed on their cell surface, mast cells secrete both preformed 
      and newly synthesized mediators of the allergic response. Blocking of these 
      responses is an objective in therapeutic intervention of allergic diseases. Thus, 
      understanding the mechanisms by which antigens elicit mast cell activation (via 
      FcepsilonRI) holds promise toward identifying therapeutic targets. Here we review 
      the most recent advances in understanding antigen-dependent mast cell activation. 
      Specifically, we focus on the requirements for FcepsilonRI activation, the 
      regulation of calcium responses, co-stimulatory signals in FcepsilonRI-mediated 
      mast cell activation and function, and how genetics influences mast cell 
      signaling and responses. These recent discoveries open new avenues of 
      investigation with therapeutic potential.
FAU - Rivera, Juan
AU  - Rivera J
AD  - Laboratory of Immune Cell Signaling, National Institute of Arthritis and 
      Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 
      Maryland, USA.
FAU - Fierro, Nora A
AU  - Fierro NA
FAU - Olivera, Ana
AU  - Olivera A
FAU - Suzuki, Ryo
AU  - Suzuki R
LA  - eng
GR  - Z01 AR041101-15/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Lysophospholipids)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, Lysosphingolipid)
RN  - 26993-30-6 (sphingosine 1-phosphate)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
RN  - EC 2.7.10.2 (lyn protein-tyrosine kinase)
RN  - EC 2.7.10.2 (src-Family Kinases)
RN  - NGZ37HRE42 (Sphingosine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Humans
MH  - Lysophospholipids/physiology
MH  - Mast Cells/*physiology
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-fyn/physiology
MH  - Receptors, IgE/*physiology
MH  - Receptors, Lysosphingolipid/physiology
MH  - Signal Transduction
MH  - Sphingosine/analogs & derivatives/physiology
MH  - src-Family Kinases/physiology
PMC - PMC2761150
MID - NIHMS150022
EDAT- 2008/09/06 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/13
CRDT- 2008/09/06 09:00
PHST- 2008/09/06 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/06 09:00 [entrez]
PHST- 2009/10/13 00:00 [pmc-release]
AID - S0065-2776(08)00403-3 [pii]
AID - 10.1016/S0065-2776(08)00403-3 [doi]
PST - ppublish
SO  - Adv Immunol. 2008;98:85-120. doi: 10.1016/S0065-2776(08)00403-3.