PMID- 18772528
OWN - NLM
STAT- MEDLINE
DCOM- 20091002
LR  - 20211203
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 72 Suppl A
DP  - 2008
TI  - Cardiac regenerative medicine.
PG  - A49-55
AB  - Severe heart failure is associated with damage to the myocardium that is 
      irreversible with current medical therapies. Recent experimental and clinical 
      studies, however, have opened the possibility of solving many of the associated 
      problems, making this an exciting and tangible goal. There are many potential 
      cell sources for regenerative cardiac medicine, including bone marrow stem cells, 
      endothelial progenitor cells, skeletal myocytes, adult cardiac stem cells, and 
      embryonic stem (ES) cells. Although ES cells are highly proliferative and 
      suitable for mass production, they are not autologous, and an efficient protocol 
      is yet to be established to ensure selective cardiomyocyte induction. Recent 
      studies have successfully established inducible pluripotent stem (iPS) cells from 
      mouse and human fibroblasts by the gene transfer of 4 transcription factors that 
      are strongly expressed in ES cells: Oct3/4, Sox2, Klf4 and c-Myc. iPS cells can 
      differentiate into all 3 germ layer-derived cells and are syngeneic, indicating 
      that they can become an ideal cell source for regenerative medicine. Despite 
      these successes, the accumulating evidence from fields as diverse as 
      developmental biology, stem cell biology and tissue engineering must be 
      integrated to achieve the full potential of cardiac regenerative medicine.
FAU - Yuasa, Shinsuke
AU  - Yuasa S
AD  - Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio 
      University School of Medicine, Tokyo, Japan.
FAU - Fukuda, Keiichi
AU  - Fukuda K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080905
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation
MH  - Cardiology/*trends
MH  - Cytological Techniques
MH  - Embryonic Stem Cells
MH  - Heart/physiopathology
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Myocardium/cytology
MH  - Pluripotent Stem Cells
MH  - Regeneration
MH  - Regenerative Medicine/*trends
MH  - Stem Cell Transplantation
MH  - Tissue Engineering/methods
RF  - 101
EDAT- 2008/09/06 09:00
MHDA- 2009/10/03 06:00
CRDT- 2008/09/06 09:00
PHST- 2008/09/06 09:00 [pubmed]
PHST- 2009/10/03 06:00 [medline]
PHST- 2008/09/06 09:00 [entrez]
AID - JST.JSTAGE/circj/CJ-08-0378 [pii]
AID - 10.1253/circj.cj-08-0378 [doi]
PST - ppublish
SO  - Circ J. 2008;72 Suppl A:A49-55. doi: 10.1253/circj.cj-08-0378. Epub 2008 Sep 5.