PMID- 18774951
OWN - NLM
STAT- MEDLINE
DCOM- 20081223
LR  - 20081121
IS  - 1600-0609 (Electronic)
IS  - 0902-4441 (Linking)
VI  - 81
IP  - 6
DP  - 2008 Dec
TI  - Incidence, risks, and outcome of idiopathic pneumonia syndrome early after 
      allogeneic hematopoietic stem cell transplantation.
PG  - 461-6
LID - 10.1111/j.1600-0609.2008.01149.x [doi]
AB  - We retrospectively analyzed 23 cases with early-onset idiopathic pneumonia 
      syndrome (IPS) of 192 patients undergoing allogeneic hematopoietic stem cell 
      transplantation (HSCT) from April 1997 to October 2007. Risk factors for IPS 
      development were evaluated using Cox proportional hazards model, including age, 
      gender, underlying disease, disease status at transplant, transplant type, 
      conditioning regimens, donor type, acute graft-vs.-host disease (GVHD), severity 
      of acute GVHD (aGVHD), human leukocyte antigen (HLA) disparity, and organ 
      involvement of aGVHD. Factors that were significant at the 0.1 level on 
      univariate analysis were evaluated by multivariate analysis. Twenty-three of 192 
      patients developed IPS (12.0%). Median time to IPS onset after allogeneic HSCT 
      was 76 d (range 32-120 d); median time to death after the diagnosis of IPS was 9 
      d (range 3-92 d); 20 patients with IPS died because of the rapid progression of 
      respiratory failure (87.0%). Nineteen patients with IPS developed aGVHD (82.6%), 
      with grade III-IV aGVHD in 11 patients (47.8%) and aGVHD of gut in 16 patients 
      (69.6%). The following six factors were associated with an increased risk of IPS 
      by univariate analysis: not in remission, unrelated donor, HLA disparity, 
      occurrence of aGVHD, grade III-IV aGVHD and aGVHD of gut. These risk factors were 
      entered into a multivariate analysis model. Only unrelated donor, grade III-IV 
      aGVHD and aGVHD of gut are identified as being significantly associated with the 
      occurrence of IPS, and among them, aGVHD of gut was associated with the largest 
      risk of IPS, suggesting that the lung may be a target organ of aGVHD.
FAU - Zhu, Kang-Er
AU  - Zhu KE
AD  - Department of Hematology, First Affiliated Hospital of Jinan University, 
      Guangzhou, China. tzhuker@jnu.edu.cn
FAU - Hu, Jun-Yan
AU  - Hu JY
FAU - Zhang, Tao
AU  - Zhang T
FAU - Chen, Jie
AU  - Chen J
FAU - Zhong, Jun
AU  - Zhong J
FAU - Lu, Yu-Hong
AU  - Lu YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080904
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/complications/*epidemiology
MH  - HLA Antigens
MH  - Hematologic Neoplasms/epidemiology/therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Incidence
MH  - Intestinal Diseases/epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Pneumonia/*epidemiology/etiology
MH  - Respiratory Insufficiency/*epidemiology/etiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Syndrome
MH  - *Transplantation Conditioning
MH  - Transplantation, Homologous
EDAT- 2008/09/09 09:00
MHDA- 2008/12/24 09:00
CRDT- 2008/09/09 09:00
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2008/12/24 09:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - EJH1149 [pii]
AID - 10.1111/j.1600-0609.2008.01149.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2008 Dec;81(6):461-6. doi: 10.1111/j.1600-0609.2008.01149.x. Epub 
      2008 Sep 4.