PMID- 18774995
OWN - NLM
STAT- MEDLINE
DCOM- 20090203
LR  - 20191210
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 9
IP  - 4 Pt 2
DP  - 2008 Aug
TI  - Annual screening detects celiac disease in children with type 1 diabetes.
PG  - 354-9
LID - 10.1111/j.1399-5448.2008.00367.x [doi]
AB  - OBJECTIVE: To investigate the prevalence of celiac disease (CD) in a cohort of 
      type 1 diabetes mellitus (T1DM) children and adolescents at the time of clinical 
      diagnosis and to evaluate the screening procedure and possible role of human 
      leukocyte antigen (HLA)-DQ during a 5-yr follow-up. RESEARCH DESIGN AND METHODS: 
      The study group was a cohort of 300 newly diagnosed T1DM children and youths 
      younger than 20 yr followed for 5 yr at six clinical centers for pediatric 
      diabetes in the region Skane in Sweden. Immunoglobulin A endomysium antibodies 
      were used to screen the patients annually to be considered for an intestinal 
      biopsy. All patients were analyzed for HLA-DQA1-B1 genotypes. RESULTS: While 0.7% 
      (2/300) already had a diagnosed symptomatic CD, an additional 3% (10/300) had 
      silent CD at the diagnosis of T1DM. During follow-up, another 6% (17/300) 
      developed CD as follows: 10 after 1 yr, 5 after 2 yr, 1 after 3 yr, and 1 after 5 
      yr. Therefore, the cumulative frequency of CD confirmed by intestinal biopsies 
      was 10% (29/300). HLA genotypes among T1DM patients developing CD were not 
      different from those among patients with T1DM alone. CONCLUSIONS: Our study 
      confirmed the low prevalence (0.7%) of diagnosed symptomatic CD at the time of 
      clinical diagnosis but document by screening an increasing prevalence of silent 
      CD during a 5-yr follow-up to reach an overall prevalence of 10%. We suggest that 
      children with T1DM should be screened for CD at the onset of T1DM and annually 
      for a minimum of at least 2 yr. HLA genotypes among T1DM patients developing CD 
      were not different from those among patients with T1DM alone.
FAU - Larsson, Karin
AU  - Larsson K
AD  - Department of Paediatrics, Kristianstad Hospital, Kristianstad, Sweden. 
      karin.larsson@litcon.se
FAU - Carlsson, Annelie
AU  - Carlsson A
FAU - Cederwall, Elisabeth
AU  - Cederwall E
FAU - Jonsson, Bjorn
AU  - Jonsson B
FAU - Neiderud, Jan
AU  - Neiderud J
FAU - Jonsson, Bjorn
AU  - Jonsson B
FAU - Lernmark, Ake
AU  - Lernmark A
FAU - Ivarsson, Sten A
AU  - Ivarsson SA
CN  - Skane Study Group
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Celiac Disease/*complications/*diagnosis/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*complications
MH  - Female
MH  - HLA-DQ Antigens
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mass Screening
MH  - Prevalence
MH  - Sweden
FIR - Kockum, K
IR  - Kockum K
FIR - Sjoblad, S
IR  - Sjoblad S
FIR - Mansson, M
IR  - Mansson M
FIR - Pelkonen, M
IR  - Pelkonen M
FIR - Heinz, J
IR  - Heinz J
FIR - Shalouie, A
IR  - Shalouie A
FIR - Nilsson, A
IR  - Nilsson A
FIR - Gustafsson, B
IR  - Gustafsson B
EDAT- 2008/09/09 09:00
MHDA- 2009/02/04 09:00
CRDT- 2008/09/09 09:00
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2009/02/04 09:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - PDI367 [pii]
AID - 10.1111/j.1399-5448.2008.00367.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2008 Aug;9(4 Pt 2):354-9. doi: 
      10.1111/j.1399-5448.2008.00367.x.