PMID- 18775690
OWN - NLM
STAT- MEDLINE
DCOM- 20081205
LR  - 20081020
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 41
IP  - 14-15
DP  - 2008 Oct
TI  - Xanthine oxidase activity in patients with sepsis.
PG  - 1186-90
LID - 10.1016/j.clinbiochem.2008.07.015 [doi]
AB  - OBJECTIVE: Determine the relation of xanthine oxidase (XO) activity and the 
      outcome of septic patients and its relation to oxidative damage and clinical 
      parameters of sepsis severity. DESIGN AND METHODS: Patients admitted over a 
      6-month period were enrolled. Patients were assigned to groups according to the 
      diagnosis of sepsis (n=8), severe sepsis (n=28) or septic shock (n=36). Blood 
      samples were collected to the determination of thiobarbituric acid reactive 
      species (TBARS), protein carbonyls and XO activity. RESULTS: None of the studied 
      oxidative parameters determined at the time of diagnosis were related to sepsis 
      severity. XO activity, but not oxidative damage parameters, at the time of sepsis 
      diagnosis was significantly higher in non-survival septic patients. In contrast, 
      24 h after sepsis diagnosis, XO activity was lower in non-survivors septic 
      patients. CONCLUSIONS: XO activity was increased in non-survivors patients and 
      the variations in XO activity could be used for outcome prediction.
FAU - Luchtemberg, Marilene N
AU  - Luchtemberg MN
AD  - Laboratorio de Fisiopatologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Petronilho, Fabricia
AU  - Petronilho F
FAU - Constantino, Larissa
AU  - Constantino L
FAU - Gelain, Daniel P
AU  - Gelain DP
FAU - Andrades, Michael
AU  - Andrades M
FAU - Ritter, Cristiane
AU  - Ritter C
FAU - Moreira, Jose Claudio F
AU  - Moreira JC
FAU - Streck, Emilio L
AU  - Streck EL
FAU - Dal-Pizzol, Felipe
AU  - Dal-Pizzol F
LA  - eng
PT  - Journal Article
DEP - 20080818
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
SB  - IM
MH  - APACHE
MH  - Demography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Protein Carbonylation
MH  - ROC Curve
MH  - Sepsis/diagnosis/*enzymology/mortality
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Xanthine Oxidase/*metabolism
EDAT- 2008/09/09 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/09/09 09:00
PHST- 2008/03/29 00:00 [received]
PHST- 2008/07/22 00:00 [revised]
PHST- 2008/07/26 00:00 [accepted]
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - S0009-9120(08)00294-4 [pii]
AID - 10.1016/j.clinbiochem.2008.07.015 [doi]
PST - ppublish
SO  - Clin Biochem. 2008 Oct;41(14-15):1186-90. doi: 10.1016/j.clinbiochem.2008.07.015. 
      Epub 2008 Aug 18.