PMID- 18776208
OWN - NLM
STAT- MEDLINE
DCOM- 20081219
LR  - 20171116
IS  - 1460-2393 (Electronic)
IS  - 1460-2393 (Linking)
VI  - 101
IP  - 11
DP  - 2008 Nov
TI  - Type 2 diabetes mellitus: a high-risk condition for cardiovascular disease 
      irrespective of the different degrees of obesity.
PG  - 875-9
LID - 10.1093/qjmed/hcn109 [doi]
AB  - BACKGROUND: Measurement of body weight with body mass index (BMI) is often 
      utilized to stratify cardiovascular disease (CVD) risk. AIM: To determine CVD 
      risk profile and disease burden in subjects with type 2 diabetes mellitus (T2DM) 
      across different categories of body weight as defined by BMI. DESIGN: Prospective 
      observational study. METHODS: CVD risk including metabolic syndrome (MetS) and 
      prevalence of macrovascular complications were determined for each category of 
      body weight as defined by the World Health Organisation (WHO) classification. 
      RESULTS: A total of 390 subjects were included in this study of which 35.9% were 
      non-obese (BMI <30 kg/m(2)). Although increasing obesity as defined by BMI was 
      associated with higher prevalence of central abdominal obesity, hypertension and 
      MetS (P < 0.05), dyslipidaemia and macrovascular complications were not 
      significantly different across the various body weight categories (P = NS). 
      Similar observation was seen in non-obese (BMI <30 kg/m(2)) and obese subjects 
      (BMI >30 kg/m(2)). Among non-obese (including normal weight) cohort, the majority 
      of these subjects had adverse CVD risk profile including presence of at least two 
      co-existing risk factors. CONCLUSION: Subjects with T2DM possess adverse CVD risk 
      factors with significant burden of macrovascular disease irrespective of their 
      baseline body weight.
FAU - Song, S H
AU  - Song SH
AD  - Diabetes Centre, Northern General Hospital, Sheffield, UK. soon_song@hotmail.com
FAU - Hardisty, C A
AU  - Hardisty CA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20080906
PL  - England
TA  - QJM
JT  - QJM : monthly journal of the Association of Physicians
JID - 9438285
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Body Weight
MH  - Cardiovascular Diseases/epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Diabetic Angiopathies/epidemiology/etiology
MH  - Humans
MH  - Metabolic Syndrome/*complications
MH  - Middle Aged
MH  - Obesity/*complications/epidemiology/metabolism
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Young Adult
EDAT- 2008/09/09 09:00
MHDA- 2008/12/20 09:00
CRDT- 2008/09/09 09:00
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2008/12/20 09:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - hcn109 [pii]
AID - 10.1093/qjmed/hcn109 [doi]
PST - ppublish
SO  - QJM. 2008 Nov;101(11):875-9. doi: 10.1093/qjmed/hcn109. Epub 2008 Sep 6.