PMID- 18776314
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20161124
IS  - 1746-8272 (Electronic)
IS  - 0261-3166 (Linking)
IP  - 52
DP  - 2008
TI  - NMR assignments and the identification of the secondary structure of the 
      anti-retroviral cytidine deaminase.
PG  - 183-4
LID - 10.1093/nass/nrn093 [doi]
AB  - APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G) is 
      known to have a role in intrinsic cellular immunity against human 
      immunodeficiency virus type1 (HIV-1). The antiretroviral activity of APOBEC3G 
      (APO3G) is associated with the hypermutation of viral DNA through cytidine 
      deamination. APO3G contains two cytidine deaminase domains that are characterised 
      by highly conserved zinc-coordinating motif. It is known that only the C-terminal 
      domain of APO3G (c-APO3G) has the catalytic activity. To shed light on the 
      molecular mechanism of action by which APO3G inactivates HIV-1, we have 
      undertaken the structural and binding studies by NMR. Here, we show the 
      achievement of backbone assignments of c-APO3G and the identification of the 
      secondary structure deduced from chemical shift index (CSI) and NOE data.
FAU - Furukawa, Ayako
AU  - Furukawa A
AD  - Supramolecular Biology, International Graduate School of Arts and Sciences, 
      Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, 
      Japan.
FAU - Nagata, Takashi
AU  - Nagata T
FAU - Habu, Yuichirou
AU  - Habu Y
FAU - Sugiyama, Ryuichi
AU  - Sugiyama R
FAU - Hayashi, Fumiaki
AU  - Hayashi F
FAU - Yokoyama, Shigeyuki
AU  - Yokoyama S
FAU - Takaku, Hiroshi
AU  - Takaku H
FAU - Katahira, Masato
AU  - Katahira M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Symp Ser (Oxf)
JT  - Nucleic acids symposium series (2004)
JID - 101259965
RN  - EC 3.5.4.5 (APOBEC-3G Deaminase)
RN  - EC 3.5.4.5 (APOBEC3G protein, human)
RN  - EC 3.5.4.5 (Cytidine Deaminase)
SB  - IM
MH  - APOBEC-3G Deaminase
MH  - Cytidine Deaminase/*chemistry
MH  - Humans
MH  - Nuclear Magnetic Resonance, Biomolecular
MH  - Protein Structure, Secondary
MH  - Structural Homology, Protein
EDAT- 2008/09/09 09:00
MHDA- 2010/11/17 06:00
CRDT- 2008/09/09 09:00
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - nrn093 [pii]
AID - 10.1093/nass/nrn093 [doi]
PST - ppublish
SO  - Nucleic Acids Symp Ser (Oxf). 2008;(52):183-4. doi: 10.1093/nass/nrn093.