PMID- 1877649
OWN - NLM
STAT- MEDLINE
DCOM- 19910923
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 261
IP  - 2 Pt 2
DP  - 1991 Aug
TI  - Pathogenesis of glomerular sclerosis in subtotally nephrectomized analbuminemic 
      rats.
PG  - F256-64
AB  - The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, 
      exhibits persistent hypercholesterolemia, thrombocytosis, and enhanced platelet 
      aggregation, abnormalities possibly involved in the genesis of glomerular 
      sclerosis (GS). Previous observations suggest that these rats never develop aging 
      GS. We studied the development of GS in NAR after 5/6 nephrectomy (Nx). Fifteen 
      days after Nx, marked glomerular hypertension was observed in NAR, compared with 
      only mild elevations in SD rats. Glomerular hypertrophy was more marked in SD 
      rats than in NAR. Enalapril normalized glomerular volume and partially reversed 
      glomerular hypertension in NAR without altering platelet function or cholesterol 
      levels. Glomerular endothelial injury and intraluminal fibrin deposition were 
      seen only in NAR. Two months after Nx, severe GS and massive glomerular lipid 
      deposition were seen in NAR, whereas only mild glomerular injury occurred in SD 
      rats. Enalapril attenuated GS and prevented lipid deposition in NAR. Glomerular 
      hypertension may be a key factor in the genesis of GS in this model in 
      association with endothelial injury, intracapillary coagulation, and lipid 
      accumulation.
FAU - Fujihara, C K
AU  - Fujihara CK
AD  - Department of Clinical Medicine, University of Sao Paulo Medical School, Brazil.
FAU - Limongi, D M
AU  - Limongi DM
FAU - Falzone, R
AU  - Falzone R
FAU - Graudenz, M S
AU  - Graudenz MS
FAU - Zatz, R
AU  - Zatz R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Animals
MH  - Arterioles/physiology
MH  - Glomerular Filtration Rate
MH  - Hemodynamics
MH  - Hypertension/physiopathology
MH  - Kidney Glomerulus/blood supply/*pathology
MH  - Male
MH  - Nephrectomy/*methods
MH  - Nephrons/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Risk Factors
MH  - Sclerosis
MH  - Serum Albumin/*analysis
MH  - Time Factors
MH  - Vascular Resistance
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1152/ajprenal.1991.261.2.F256 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Aug;261(2 Pt 2):F256-64. doi: 
      10.1152/ajprenal.1991.261.2.F256.