PMID- 18776501
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20131121
IS  - 1746-8272 (Electronic)
IS  - 0261-3166 (Linking)
IP  - 52
DP  - 2008
TI  - Synthetic study of muraymycins using Ugi-four component reaction.
PG  - 557-8
LID - 10.1093/nass/nrn282 [doi]
AB  - The synthetic study of muraymycins (MRYs), which have potent antibacterial 
      activity, is described. The key elements of our approach include the synthesis of 
      L-epicapreomycidine via a C-H amination reaction and a conversient assemblage to 
      construct of the framework of muraymycins using Ugi-four component reaction. 
      First, isonitrile 4 was prepared from uridine in 14 steps. The precursor of 
      carboxylic acid component 15 was synthesised via the C-H amination reaction, 
      formation of cyclic guanidine structure. Muraymycin D2 analogs were synthesized 
      by a model Ugi-four component reaction.
FAU - Tanino, Tetsuya
AU  - Tanino T
AD  - Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 
      060-0812, Japan.
FAU - Hirano, Shinpei
AU  - Hirano S
FAU - Ichikawa, Satoshi
AU  - Ichikawa S
FAU - Matsuda, Akira
AU  - Matsuda A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nucleic Acids Symp Ser (Oxf)
JT  - Nucleic acids symposium series (2004)
JID - 101259965
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Nitriles)
RN  - 0 (Nucleosides)
RN  - 0 (Peptides)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Anti-Bacterial Agents/*chemical synthesis/chemistry
MH  - Nitriles/chemical synthesis/chemistry
MH  - Nucleosides/*chemical synthesis/chemistry
MH  - Peptides/chemistry
MH  - Urea/*chemistry
EDAT- 2008/09/09 09:00
MHDA- 2010/11/17 06:00
CRDT- 2008/09/09 09:00
PHST- 2008/09/09 09:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PHST- 2008/09/09 09:00 [entrez]
AID - nrn282 [pii]
AID - 10.1093/nass/nrn282 [doi]
PST - ppublish
SO  - Nucleic Acids Symp Ser (Oxf). 2008;(52):557-8. doi: 10.1093/nass/nrn282.