PMID- 18778953
OWN - NLM
STAT- MEDLINE
DCOM- 20090309
LR  - 20211020
IS  - 1044-5323 (Print)
IS  - 1044-5323 (Linking)
VI  - 21
IP  - 1
DP  - 2009 Feb
TI  - Retinoic acid-dependent regulation of immune responses by dendritic cells and 
      macrophages.
PG  - 22-7
LID - 10.1016/j.smim.2008.07.007 [doi]
AB  - Dendritic cells (DCs) control the strength and quality of antigen-specific T and 
      B cell responses. Recent advances point to a novel mechanism, in which metabolism 
      of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of 
      lymphocyte differentiation. First, RA enhances the induction of Foxp3(+) T 
      regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages 
      constitutively express RA synthesizing enzymes, and induce T regulatory cells. In 
      addition, RA programs DCs to imprint mucosal homing properties on activated T and 
      B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we 
      review these recent advances, in the context of the pleiotropic effects of RA in 
      regulating diverse biological processes.
FAU - Manicassamy, Santhakumar
AU  - Manicassamy S
AD  - Emory Vaccine Center & Yerkes National Primate Research Center, 954 Gatewood 
      Road, Atlanta, GA 30329, USA.
FAU - Pulendran, Bali
AU  - Pulendran B
LA  - eng
GR  - R37 AI048638/AI/NIAID NIH HHS/United States
GR  - U19 AI057266-010002/AI/NIAID NIH HHS/United States
GR  - R01 DK057665/DK/NIDDK NIH HHS/United States
GR  - N01AI50019/AI/NIAID NIH HHS/United States
GR  - R21 AI056947-01A1/AI/NIAID NIH HHS/United States
GR  - R56 AI048638-09/AI/NIAID NIH HHS/United States
GR  - DK057665/DK/NIDDK NIH HHS/United States
GR  - U54 AI057157-06S10017/AI/NIAID NIH HHS/United States
GR  - R21 AI056947/AI/NIAID NIH HHS/United States
GR  - U54 AI057157/AI/NIAID NIH HHS/United States
GR  - U19 AI057266-05S10002/AI/NIAID NIH HHS/United States
GR  - AI048638/AI/NIAID NIH HHS/United States
GR  - U19 AI057266/AI/NIAID NIH HHS/United States
GR  - AI05726601/AI/NIAID NIH HHS/United States
GR  - R01 AI048638-08/AI/NIAID NIH HHS/United States
GR  - R56 AI048638/AI/NIAID NIH HHS/United States
GR  - R37 DK057665/DK/NIDDK NIH HHS/United States
GR  - R01 AI048638-05A1/AI/NIAID NIH HHS/United States
GR  - R01 DK057665-09/DK/NIDDK NIH HHS/United States
GR  - R01 DK057665-10/DK/NIDDK NIH HHS/United States
GR  - R01 AI048638/AI/NIAID NIH HHS/United States
GR  - R01 AI048638-07/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080907
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
RN  - 0 (Receptors, Retinoic Acid)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/metabolism
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Gastrointestinal Tract/*immunology/metabolism
MH  - Humans
MH  - Macrophages/*immunology/metabolism
MH  - Receptors, Retinoic Acid/immunology/*metabolism
MH  - Signal Transduction/immunology
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
MH  - Tretinoin/immunology/*metabolism
PMC - PMC2642591
MID - NIHMS84824
EDAT- 2008/09/10 09:00
MHDA- 2009/03/10 09:00
PMCR- 2010/02/01
CRDT- 2008/09/10 09:00
PHST- 2008/07/03 00:00 [received]
PHST- 2008/07/28 00:00 [revised]
PHST- 2008/07/30 00:00 [accepted]
PHST- 2008/09/10 09:00 [pubmed]
PHST- 2009/03/10 09:00 [medline]
PHST- 2008/09/10 09:00 [entrez]
PHST- 2010/02/01 00:00 [pmc-release]
AID - S1044-5323(08)00061-4 [pii]
AID - 10.1016/j.smim.2008.07.007 [doi]
PST - ppublish
SO  - Semin Immunol. 2009 Feb;21(1):22-7. doi: 10.1016/j.smim.2008.07.007. Epub 2008 
      Sep 7.