PMID- 1878008
OWN - NLM
STAT- MEDLINE
DCOM- 19910925
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 88
IP  - 1
DP  - 1991 May
TI  - Hyperlipoproteinemia in one-year-old analbuminemic rats.
PG  - 35-47
AB  - Plasma lipoprotein distribution and apolipoprotein concentrations, as well as 
      kidney function and histopathology of heart, aorta, liver and kidney were 
      investigated in 1-year-old Nagase analbuminemic rats (NAR) and control 
      Sprague-Dawley rats (SDR). The NAR, particularly the females, were found to be 
      severely hyperlipidemic. Plasma total cholesterol in non-fasted animals was 6.1 
      +/- 0.3 mM in the female NAR vs. 2.5 +/- 0.2 mM in the female SDR (P less than 
      0.01). Most of the cholesterol was located in the LDL (1.019-1.063 g/ml) and HDL2 
      (1.063-1.125 g/ml) density range. Plasma triglycerides were 6.1 +/- 0.6 mM in the 
      female NAR vs. 1.3 +/- 0.3 mM (P less than 0.01) in the female SDR. Plasma 
      phospholipids were raised up to 5.4 +/- 0.3 mM vs. 2.4 +/- 0.1 mM (P less than 
      0.01). NAR have increased concentrations of plasma apolipoproteins A-I (about 
      3-4-fold) and B (about 2-fold), but the levels of apolipoproteins A-IV and E are 
      not increased. There was less proteinuria in the male NAR than in the male SDR (P 
      less than 0.01). Relevant histopathological findings in the NAR included 
      hepatocytic lipofuscinosis and hemosiderosis in Kupffer cells. Tubular lesions 
      were more common in kidneys from NAR than from SDR, and included protein casts, 
      cortical lipofuscinosis, proximal tubular hyperplasia and proliferative 
      interstitial nephritis. Glomerular changes were similar in both strains. 
      Calcinosis of the aortic media and the corticomedullary region of the kidney was 
      characteristically present in the female SDR but absent in the female NAR. 
      Atherosclerotic lesions were not observed. In summary, 1-year-old NAR maintained 
      on standard rat chow, are hyperlipoproteinemic. The increased levels of plasma 
      LDL and HDL cholesterol are not associated with an increase in the incidence or 
      severity of atherosclerotic or glomerular lesions.
FAU - Joles, J A
AU  - Joles JA
AD  - Department of Nephrology, Medical Faculty, University of Utrecht, The 
      Netherlands.
FAU - Willekes-Koolschijn, N
AU  - Willekes-Koolschijn N
FAU - van Tol, A
AU  - van Tol A
FAU - Geelhoed-Mieras, M M
AU  - Geelhoed-Mieras MM
FAU - Danse, L H
AU  - Danse LH
FAU - van Garderen, E
AU  - van Garderen E
FAU - Kortlandt, W
AU  - Kortlandt W
FAU - Erkelens, D W
AU  - Erkelens DW
FAU - Koomans, H A
AU  - Koomans HA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Animals
MH  - Aorta/pathology
MH  - Arteriosclerosis/complications/pathology
MH  - Blood Pressure
MH  - Female
MH  - Hyperlipoproteinemias/*blood/complications/pathology/physiopathology
MH  - Kidney/pathology/physiopathology
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Liver/pathology
MH  - Male
MH  - Myocardium/pathology
MH  - Organ Size
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serum Albumin/*deficiency
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 0021-9150(91)90255-2 [pii]
AID - 10.1016/0021-9150(91)90255-2 [doi]
PST - ppublish
SO  - Atherosclerosis. 1991 May;88(1):35-47. doi: 10.1016/0021-9150(91)90255-2.