PMID- 18780165
OWN - NLM
STAT- MEDLINE
DCOM- 20090511
LR  - 20211020
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 29
IP  - 2
DP  - 2009 Mar
TI  - HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the 
      patients with pemphigus vulgaris.
PG  - 175-9
LID - 10.1007/s10875-008-9244-x [doi]
AB  - INTRODUCTION: Pemphigus vulgaris (PV), an autoimmune disease affecting the skin 
      and mucous membranes, is associated with some human leukocyte antigen (HLA) class 
      II alleles and haplotypes. MATERIALS AND METHODS: In order to evaluate the 
      association of HLA-DR and DQ alleles and haplotypes in Iranian non-Jewish 
      patients with PV, 52 patients with PV and 180 normal subjects as control group 
      were investigated in this study. RESULTS AND DISCUSSION: HLA-DRB1*04, -DRB1*1401, 
      -DRB4, -DQA1*0104, -DQA1*03011, -DQB1*0302, and -DQB1*0502 alleles have been 
      significantly increased in our patients group. Moreover, the haplotypes 
      HLA-DRB1*04/-DQA1*03011/-DQB1*0302 and HLA-DRB1*1401/-DQA1*0104/-DQB1*0502 
      increased significantly in our patients. In contrast, the following alleles 
      decreased significantly in our patients: HLA-DRB1*15, -DRB1*0301, -DRB1*07, 
      -DRB1*11, -DRB5, -DQA1*0101, -DQA1*0103, -DQA1*201, -DQA1*05, -DQB1*0201, 
      -DQB1*0301, -DQB1*06011, and -DQB1*0602. In addition, 
      HLA-DRB1*15/-DQA1*0103/-DQB1*06011, HLA-DRB1*0301/-DQA1*05011/-DQB1*0201, 
      HLA-DRB1*07/-DQA1*0201/-DQB1*0201, and HLA-DRB1*11/-DQA1*05/-DQB1*03011 decreased 
      significantly in our patients. Genetic factors are involved in the occurrence of 
      PV; HLA-DRB1*04 and -DRB1*1401 alleles and the related haplotypes are suggestive 
      to be two major PV susceptibility factors in our population study.
FAU - Shams, Sheida
AU  - Shams S
AD  - Department of Dermatology, Razi Hospital, School of Medicine, Tehran University 
      of Medical Sciences, Tehran, Iran.
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
FAU - Yousefi, Maryam
AU  - Yousefi M
FAU - Rezaei, Nima
AU  - Rezaei N
FAU - Solgi, Ghasem
AU  - Solgi G
FAU - Khosravi, Farideh
AU  - Khosravi F
FAU - Ansaripour, Bita
AU  - Ansaripour B
FAU - Moradi, Batoul
AU  - Moradi B
FAU - Nikbin, Behrouz
AU  - Nikbin B
LA  - eng
PT  - Journal Article
DEP - 20080909
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Alleles
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Membrane Glycoproteins/*genetics
MH  - Pemphigus/epidemiology/*genetics
EDAT- 2008/09/10 09:00
MHDA- 2009/05/12 09:00
CRDT- 2008/09/10 09:00
PHST- 2008/07/29 00:00 [received]
PHST- 2008/08/13 00:00 [accepted]
PHST- 2008/09/10 09:00 [pubmed]
PHST- 2009/05/12 09:00 [medline]
PHST- 2008/09/10 09:00 [entrez]
AID - 10.1007/s10875-008-9244-x [doi]
PST - ppublish
SO  - J Clin Immunol. 2009 Mar;29(2):175-9. doi: 10.1007/s10875-008-9244-x. Epub 2008 
      Sep 9.