PMID- 18781277
OWN - NLM
STAT- MEDLINE
DCOM- 20090305
LR  - 20211020
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 115
IP  - 12
DP  - 2008 Dec
TI  - Brain-derived neurotrophic factor gene variation influences cerebrospinal fluid 
      3-methoxy-4-hydroxyphenylglycol concentrations in healthy volunteers.
PG  - 1695-9
LID - 10.1007/s00702-008-0113-9 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been shown to influence monoamine 
      transmitter synthesis, metabolism and release. We investigated possible 
      relationships between four BDNF gene polymorphisms and cerebrospinal fluid (CSF) 
      concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), 
      and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 132). All 
      BDNF polymorphisms (270 C/T, -633 T/A, Val66Met, and 11757 G/C) were associated 
      with MHPG (P < 0.02), but not with 5-HIAA and HVA concentrations. At a second 
      clinical investigation 8-20 years after CSF sampling 30% of the subjects had 
      experienced various psychiatric disorders. Development of a psychiatric disorder 
      was predicted by low 5-HIAA concentrations (P = 0.01). The results suggest that 
      BDNF gene variation participates in regulation of norepinephrine turnover rates 
      in the central nervous system of human subjects.
FAU - Jonsson, Erik G
AU  - Jonsson EG
AD  - Department of Clinical Neuroscience, Karolinska Institute and Hospital, 
      Stockholm, Sweden. erik.jonsson@ki.se
FAU - Saetre, Peter
AU  - Saetre P
FAU - Edman-Ahlbom, Bodil
AU  - Edman-Ahlbom B
FAU - Sillen, Anna
AU  - Sillen A
FAU - Gunnar, Agneta
AU  - Gunnar A
FAU - Andreou, Dimitrios
AU  - Andreou D
FAU - Agartz, Ingrid
AU  - Agartz I
FAU - Sedvall, Goran
AU  - Sedvall G
FAU - Hall, Hakan
AU  - Hall H
FAU - Terenius, Lars
AU  - Terenius L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080910
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - Adult
MH  - Brain/*metabolism
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Homovanillic Acid/analysis/cerebrospinal fluid
MH  - Humans
MH  - Hydroxyindoleacetic Acid/analysis/cerebrospinal fluid
MH  - Male
MH  - Methoxyhydroxyphenylglycol/analysis/*cerebrospinal fluid
MH  - Neurocognitive Disorders/genetics/metabolism/physiopathology
MH  - Norepinephrine/*metabolism
MH  - Polymorphism, Genetic/*genetics
MH  - Predictive Value of Tests
MH  - Serotonin/metabolism
MH  - Young Adult
EDAT- 2008/09/11 09:00
MHDA- 2009/03/06 09:00
CRDT- 2008/09/11 09:00
PHST- 2008/06/10 00:00 [received]
PHST- 2008/08/15 00:00 [accepted]
PHST- 2008/09/11 09:00 [pubmed]
PHST- 2009/03/06 09:00 [medline]
PHST- 2008/09/11 09:00 [entrez]
AID - 10.1007/s00702-008-0113-9 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2008 Dec;115(12):1695-9. doi: 
      10.1007/s00702-008-0113-9. Epub 2008 Sep 10.