PMID- 18781279
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20211020
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 91
IP  - 1
DP  - 2009 Jan
TI  - Chromosome 1p and 19q deletions in malignant glioneuronal tumors with 
      oligodendroglioma-like component.
PG  - 33-8
LID - 10.1007/s11060-008-9690-6 [doi]
AB  - Malignant glioneuronal tumors (MGNT) are suggested to be a new entity of glioma 
      defined morphologically as any malignant glioma showing immunohistoichemical 
      evidence of neuronal differentiation. We encountered seven cases of MGNT with 
      oligodendroglioma-like component and investigated alternations of chromosome 1p 
      and 19q in these tumors. Seven patients ranged from 33 to 62 years of age, four 
      females and three males. Immunohistochemical study of these tumors was performed 
      using neuronal markers (synaptophysin, neurofilament, beta-tubulin, chromogranin 
      A and NeuN), astrocytic marker (GFAP) and Ki-67. We undertook a molecular 
      cytogenetic study of tumor specimens obtained from seven patients using 
      fluorescence in situ hybridization (FISH) with DNA probes mapping to chromosome 
      1p36, 1q25, 19p13 and 19q13. Histologically, these tumors resembled anaplastic 
      oligodendroglioma. Immunohistochemically, tumor cells were immunoreactive for 
      synaptophysin (7/7), neurofilament (6/7), beta-tubulin (5/7), chromogranin A 
      (4/7), NeuN (2/7) and GFAP (7/7). The Ki-67 labeling index ranged from 4.5% to 
      20.7%. FISH analysis demonstrated either 1p or 19q deletion in all seven cases 
      (100%) and both 1p and 19q deletions in five cases (71%). The 1p deletion was 
      detected in six of seven cases (86%) and 19q deletion was also detected in six 
      (86%). 1p and 19q deletions were present in MGNT, especially those with 
      oligodendroglial components. We suggest that the oligodendroglial-like feature 
      was associated with not only 1p or 19q loss but also differentiation along 
      neuronal cell lines as a factor of favorable prognosis in glial tumors. It is 
      inappropriate to make a diagnosis of oligodendroglioma based only on 
      morphological resemblance to oligodendroglia.
FAU - Takeuchi, Hiroaki
AU  - Takeuchi H
AD  - Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 
      23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan. takeu@u-fukui.ac.jp
FAU - Kubota, Toshihiko
AU  - Kubota T
FAU - Kitai, Ryuhei
AU  - Kitai R
FAU - Matsuda, Ken
AU  - Matsuda K
FAU - Hashimoto, Norichika
AU  - Hashimoto N
FAU - Sato, Kazufumi
AU  - Sato K
LA  - eng
PT  - Journal Article
DEP - 20080910
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/genetics/*metabolism
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 19
MH  - Female
MH  - Humans
MH  - Ki-67 Antigen/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/metabolism
MH  - Oligodendroglia/metabolism/pathology
MH  - Oligodendroglioma/genetics/*metabolism
EDAT- 2008/09/11 09:00
MHDA- 2009/04/29 09:00
CRDT- 2008/09/11 09:00
PHST- 2008/06/10 00:00 [received]
PHST- 2008/08/11 00:00 [accepted]
PHST- 2008/09/11 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
PHST- 2008/09/11 09:00 [entrez]
AID - 10.1007/s11060-008-9690-6 [doi]
PST - ppublish
SO  - J Neurooncol. 2009 Jan;91(1):33-8. doi: 10.1007/s11060-008-9690-6. Epub 2008 Sep 
      10.