PMID- 1878246
OWN - NLM
STAT- MEDLINE
DCOM- 19911003
LR  - 20220309
IS  - 1011-0283 (Print)
IS  - 1011-0283 (Linking)
VI  - 4
IP  - 2
DP  - 1991
TI  - Transforming growth factor alpha: in vivo release by normal human skin following 
      UV irradiation and abrasion.
PG  - 61-4
AB  - Transforming growth factor alpha (TGF alpha) is a keratinocyte-growth-stimulating 
      factor which may have a role in epidermal hyperproliferation, psoriasis, and 
      wound healing. Since increased epidermal proliferation occurs in response to UV 
      radiation, we have measured the amount of TGF alpha in exudates from normal and 
      UVB-irradiated human skin. Cutaneous exudates were obtained using the skin 
      chamber abrasion technique from one side of the back of volunteers (n = 10) with 
      normal skin (collected following skin contact times of 2 and 30 min). Exudates 
      were similarly obtained from the contralateral side of the back at sites 
      irradiated 2 h previously with 3 x the minimum erythemal dose UVB. Levels of TGF 
      alpha were measured by radioimmunoassay. Normal human skin released TGF alpha 
      immediately after abrasion: unirradiated, 63 +/- 18 ng/ml; irradiated, 89 +/- 15 
      ng/ml. Levels of TGF alpha increased within 30 min to 110 +/- 14 ng/ml in 
      unirradiated skin and to 190 +/- 17 ng/ml in irradiated skin. Irradiated sites at 
      30-min time points were significantly higher (p less than 0.05) than all other 
      samples. The presence of releasable TGF alpha in normal skin suggests a role for 
      TGF alpha in wound repair mechanisms.
FAU - James, L C
AU  - James LC
AD  - Allergen Inc., Biological Sciences and Herbert Laboratories, Irvine, Calif.
FAU - Moore, A M
AU  - Moore AM
FAU - Wheeler, L A
AU  - Wheeler LA
FAU - Murphy, G M
AU  - Murphy GM
FAU - Dowd, P M
AU  - Dowd PM
FAU - Greaves, M W
AU  - Greaves MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Skin Pharmacol
JT  - Skin pharmacology : the official journal of the Skin Pharmacology Society
JID - 8810069
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Adolescent
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - Male
MH  - Radioimmunoassay
MH  - Skin/*metabolism/physiopathology/radiation effects
MH  - Transforming Growth Factor alpha/*metabolism
MH  - *Ultraviolet Rays
MH  - Wound Healing/physiology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1159/000210925 [doi]
PST - ppublish
SO  - Skin Pharmacol. 1991;4(2):61-4. doi: 10.1159/000210925.