PMID- 18782527
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20080910
IS  - 1672-1977 (Print)
IS  - 1672-1977 (Linking)
VI  - 6
IP  - 9
DP  - 2008 Sep
TI  - Transparently reporting adverse effects of traditional Chinese medicine 
      interventions in randomized controlled trials.
PG  - 881-6
LID - 10.3736/jcim20080901 [doi]
AB  - Although all Chinese materia medica (CMM) come from nature, CMM interventions 
      have both therapeutic effects and adverse effects (AEs). Normally, AEs in 
      randomized controlled trial (RCT) with traditional Chinese medicine (TCM) could 
      be divided into five types as follows: 1) AEs under proper TCM principles and 
      guidelines, such as the toxicity (acute and chronic) and allergy; 2) AEs due to 
      improper usage without following TCM principles, involving without following the 
      TCM therapeutic principles, over-dosage, improper processing and preparation 
      methods, improper formula strategy, etc; 3) AEs due to contamination in CMM, such 
      as heavy metal and pesticides contaminations in Chinese herbal medicine 
      interventions, and intentional or unintentional contamination with drug(s); 4) 
      AEs due to replacement of CMMs; 5) AEs due to drug-herb interaction. AEs of TCM 
      should be treated properly. Overestimation or underestimation about AEs of TCM 
      intervention will bring a wrong message to patients and health care providers. In 
      order to give readers a more comprehensive understanding about the safety issue 
      of study intervention, Consolidated Standards of Reporting Trials (CONSORT) for 
      TCM should involve the background information on side effects of each CMM 
      constituents and/or the study intervention, specific outcome assessment on AEs, 
      the details of reported AEs and the interpretation of the AEs occurrence in a 
      structural RCT report.
FAU - Cheng, Chung-Wah
AU  - Cheng CW
FAU - Bian, Zhao-Xiang
AU  - Bian ZX
FAU - Li, You-Ping
AU  - Li YP
FAU - Moher, David
AU  - Moher D
FAU - Wu, Tai-Xiang
AU  - Wu TX
FAU - Dagenais, Simon
AU  - Dagenais S
FAU - Li, Jing
AU  - Li J
FAU - Li, Ting-Qian
AU  - Li TQ
LA  - eng
PT  - Editorial
PL  - China
TA  - Zhong Xi Yi Jie He Xue Bao
JT  - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
JID - 101199657
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Materia Medica)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - China
MH  - Drug Contamination
MH  - Drug Interactions
MH  - Drugs, Chinese Herbal/*adverse effects/standards
MH  - Humans
MH  - Materia Medica/*adverse effects
MH  - Medicine, Chinese Traditional/methods/*standards
MH  - Metals, Heavy/toxicity
MH  - Publishing
MH  - Randomized Controlled Trials as Topic/methods/*standards
MH  - Research Design/standards
EDAT- 2008/09/11 09:00
MHDA- 2010/08/20 06:00
CRDT- 2008/09/11 09:00
PHST- 2008/09/11 09:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
PHST- 2008/09/11 09:00 [entrez]
AID - 167219772008090881 [pii]
AID - 10.3736/jcim20080901 [doi]
PST - ppublish
SO  - Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):881-6. doi: 10.3736/jcim20080901.