PMID- 18783520
OWN - NLM
STAT- MEDLINE
DCOM- 20081016
LR  - 20080911
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 13 Suppl 1
DP  - 2008 Oct
TI  - Treatment of Helicobacter pylori infection.
PG  - 35-40
LID - 10.1111/j.1523-5378.2008.00639.x [doi]
AB  - Antibiotic resistance has resulted in unsatisfactory eradication results with 
      dual and now triple therapy in many countries. Newer antibiotics and changes in 
      dosing and duration of therapy may overcome resistant strains but may only 
      provide limited improvement in eradication rates. Sequential therapy with 
      amoxicillin (1 g twice a day) and a proton pump inhibitor (PPI) (twice a day) 
      given for 5 days followed by a PPI plus clarithromycin (500 mg twice a day) and 
      tinidazole (500 mg twice a day) for 5 days is now a first-line therapy for 
      Helicobacter pylori in some countries. Standard triple therapy is effective in 
      regions where clarithromycin resistance is low. Levofloxacin based triple therapy 
      is an effective alternative to quadruple therapy in second-line treatment. 
      Adjuvant therapy may reduce side-effects and improve compliance. Molecular and 
      genomic research on H. pylori may result in the development of targeted 
      antibiotic therapy; however, more research is required in this field. Further 
      research in vaccination is also necessary before this can become an option in 
      clinical practice.
FAU - Egan, Brian J
AU  - Egan BJ
AD  - Department of Gastroenterology, Adelaide and Meath Hospital incorporating 
      National Children's Hospital Tallaght, Trinity College Dublin, Ireland. 
      eganbr@tcd.ie
FAU - Marzio, Leonardo
AU  - Marzio L
FAU - O'Connor, Humphrey
AU  - O'Connor H
FAU - O'Morain, Colm
AU  - O'Morain C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Chemotherapy, Adjuvant
MH  - Drug Administration Schedule
MH  - Drug Resistance, Bacterial
MH  - Drug Therapy, Combination
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/*drug effects
MH  - Humans
MH  - Proton Pump Inhibitors/administration & dosage
MH  - Treatment Outcome
EDAT- 2008/09/12 09:00
MHDA- 2008/10/17 09:00
CRDT- 2008/09/12 09:00
PHST- 2008/09/12 09:00 [pubmed]
PHST- 2008/10/17 09:00 [medline]
PHST- 2008/09/12 09:00 [entrez]
AID - HEL639 [pii]
AID - 10.1111/j.1523-5378.2008.00639.x [doi]
PST - ppublish
SO  - Helicobacter. 2008 Oct;13 Suppl 1:35-40. doi: 10.1111/j.1523-5378.2008.00639.x.