PMID- 18784451
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20211020
IS  - 1011-8942 (Print)
IS  - 1011-8942 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Sep
TI  - Bilateral toxoplasma retinochoroiditis simulating cytomegalovirus retinitis in an 
      allogeneic bone marrow transplant patient.
PG  - 197-200
LID - 10.3341/kjo.2008.22.3.197 [doi]
AB  - A 36-year old female with acute myelogenous leukemia presented with a sudden 
      decrease in vision one month following bone marrow transplantation (BMT). She had 
      been taking multiple immunosuppressants to treat her recently-developed 
      graft-versus-host-disease (GVHD). Visual acuity was 20/60 in her right eye and 
      20/25 in her left. Ophthalmic examination revealed mild inflammatory reaction in 
      both the anterior chamber and the vitreous of both eyes, as well as densely 
      opaque yellow-white infiltrates with well-demarcated borders in the posterior 
      retina of both eyes. She was originally diagnosed as CMV retinitis, but treatment 
      with ganciclovir failed to improve her ocular condition. Subsequent work-up, 
      including serology and brain MRI, led to a diagnosis of combined ocular and 
      cerebral toxoplasmosis. After 6 weeks of antiparasitic therapy, her retinal 
      lesions became inactive and her cerebral lesions improved. Immunosuppressed 
      patients with necrotizing retinochoroiditis should be suspected of having 
      toxoplasmosis. Accurate differentiation between this condition and CMV, and early 
      intervention with the appropriate treatment may be critical to preserve the best 
      vision.
FAU - Chung, Hyewon
AU  - Chung H
AD  - Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of 
      Medicine, Seoul, Korea.
FAU - Kim, June Gone
AU  - Kim JG
FAU - Choi, Sang Ho
AU  - Choi SH
FAU - Lee, Sun Young
AU  - Lee SY
FAU - Yoon, Young Hee
AU  - Yoon YH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Ophthalmol
JT  - Korean journal of ophthalmology : KJO
JID - 8804513
RN  - 0 (Anti-Bacterial Agents)
RN  - 3U02EL437C (Clindamycin)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - *Bone Marrow Transplantation
MH  - Chorioretinitis/*diagnosis/drug therapy/parasitology
MH  - Clindamycin/therapeutic use
MH  - Cytomegalovirus Retinitis/*diagnosis
MH  - Drug Therapy, Combination
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*surgery
MH  - Magnetic Resonance Imaging
MH  - Tomography, Optical Coherence
MH  - Toxoplasmosis, Cerebral/*diagnosis/drug therapy
MH  - Toxoplasmosis, Ocular/*diagnosis/drug therapy
MH  - Transplantation, Homologous
MH  - Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
PMC - PMC2629896
EDAT- 2008/09/12 09:00
MHDA- 2008/11/18 09:00
PMCR- 2008/09/01
CRDT- 2008/09/12 09:00
PHST- 2008/09/12 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/09/12 09:00 [entrez]
PHST- 2008/09/01 00:00 [pmc-release]
AID - 200809197 [pii]
AID - 10.3341/kjo.2008.22.3.197 [doi]
PST - ppublish
SO  - Korean J Ophthalmol. 2008 Sep;22(3):197-200. doi: 10.3341/kjo.2008.22.3.197.