PMID- 18784884
OWN - NLM
STAT- MEDLINE
DCOM- 20150516
LR  - 20181201
IS  - 1006-7248 (Print)
IS  - 1006-7248 (Linking)
VI  - 17
IP  - 4
DP  - 2008 Aug
TI  - [The level of PPTA mRNA and its proteins expression in trigeminal ganglia in rats 
      with occlusal recovery].
PG  - 411-5
AB  - PURPOSE: To study the level of substance P(SP) and preprotachykinin A(PPTA) mRNA 
      in trigeminal ganglia(TG)in rats with occlusal recoveryiand to discuss the 
      mechanism of temporomandibular disorders. METHODS: 48 Wistar male rats were 
      randomly divided into 3 experimental groups and 3 control groupsi8 rats in each 
      group. The right maxillary and mandibular molars in the experimental groups were 
      ground to the gingival level without occlusal contact. The occlusal contact was 
      recovered by stoping grinding the molars gradually. The section of trigeminal 
      ganglia were used for immunohistological and in situ hybridization study. Light 
      microscope and microscoic photo analytic software were employed to detect the 
      percentage of SP and PPTA mRNA positive neurons in the frozen section of TGs in 
      48 rats. SPSS10.0 software package were used for statistical analysis. RESULTS: 
      The percentage of SP positive neurons in TG with unilateral chew experimental 
      group decreased significantly compared to the control group (P<0.01,P<0.05).The 
      decreased extent in the non-chewing side was much higher than that in the chewing 
      side(P<0.05).The percentage of PPTA mRNA positive neurons was significantly 
      higher in both of the chewing and non-chewing sides of the unilateral chew 
      experimental group than that in the control group (P<0.05,P<0.01)i and that 
      non-chewing side was significantly higher than that in the chewing 
      side(P<0.01).There was no significant difference in the percentage of SP and PPTA 
      mRNA positive neurons between the early occlusal reconstruction the experimental 
      group and the control group(P>0.05), and there was no significant difference of 
      those between the non-chewing side and the chewing side(P>0.05). The results of 
      later occlusal recovery in the experimental group was same to that of the 
      unilateral chew experimental group. CONCLUSIONS: The expressions of SP and PPTA 
      mRNA in TG can recover normal in the early occlusal recovery but can not in the 
      later occlusal recovery. SP and PPTA mRNA might participate in the 
      histopathologic mechanism of temporomandibular disorders.
FAU - Li, Xiao-guang
AU  - Li XG
AD  - Department of Stomatology, Taian Central Hospital, Taian 271000, Shandong 
      Province, China. lxg0538@163.com
FAU - Gao, De-an
AU  - Gao DA
FAU - Jin, Song
AU  - Jin S
FAU - Wang, Yan-xiu
AU  - Wang YX
FAU - Qi, Chun-hua
AU  - Qi CH
FAU - Zhu, Sheng-rong
AU  - Zhu SR
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Shanghai Kou Qiang Yi Xue
JT  - Shanghai kou qiang yi xue = Shanghai journal of stomatology
JID - 101090220
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tachykinins)
RN  - 0 (preprotachykinin)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Gingiva
MH  - Male
MH  - Protein Precursors/*metabolism
MH  - RNA, Messenger
MH  - Rats
MH  - Rats, Wistar
MH  - Substance P/*metabolism
MH  - Tachykinins/*metabolism
MH  - Trigeminal Ganglion/*metabolism
EDAT- 2008/09/12 09:00
MHDA- 2015/05/20 06:00
CRDT- 2008/09/12 09:00
PHST- 2008/09/12 09:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PHST- 2008/09/12 09:00 [entrez]
AID - 2229 [pii]
PST - ppublish
SO  - Shanghai Kou Qiang Yi Xue. 2008 Aug;17(4):411-5.