PMID- 18785407
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20080912
IS  - 1009-2587 (Print)
IS  - 1009-2587 (Linking)
VI  - 24
IP  - 2
DP  - 2008 Apr
TI  - [Effects of stimulation of intact vagus nerve on systemic inflammatory response 
      in rats].
PG  - 99-101
AB  - OBJECTIVE: To observe the effects of stimulation of intact vagus nerve (IVNS) on 
      systemic inflammatory response in rats. METHODS: The model of systemic 
      inflammatory response was reproduced by lipopolysaccharide (LPS). One hundred 
      Sprague Dawley rats were randomly divided into A group (with intravenous 
      injection of LPS), B group (with stimulation of efferent nerve trunk of vagus 
      nerve after intravenous injection of lipopolysaccharide and vagotomy), C group 
      (with stimulation of intact vagus nerve after intravenous injection of LPS), D 
      group (with vagus nerve stimulation after injection of equivalent isotonic 
      saline), E group (with intravenous injection of equivalent isotonic saline), with 
      20 rats in each group. Five rats of each group were used to determine mean aortic 
      pressure (MAP) before injection and l0 min, 0.5 h, 1 h, 2 h, 4 h and 6 h after 
      injection. The serum levels of tumor necrosis factor (TNF) alpha and interleukin 
      (IL) 10 were determined with enzyme linked immunosorbent assay before injection 
      and 2, 4 and 6 hour after injection. RESULTS: The level of MAP rose in A, B, C 
      groups at 10 min after injection, especially in A group (134.40 +/- 7.3 mm Hg, l 
      mm Hg = 0.033 kPa, P < 0.05), but it dropped in above groups at 30 min after 
      injection. The level of MAP in A group was obviously lower than that in B, C 
      groups during 10 min -6 h after injection. The serum level of TNF-alpha in A 
      group was significantly higher than that in B, C groups at 2, 4, 6 hours after 
      injection (P < 0.05). Compared with that in C group, the serum level of IL-10 in 
      A, B groups lowered markedly at 4, 6 hours after injection (P < 0.05). 
      CONCLUSION: IVNS can stabilize hemodynamics and exert have anti-inflammatory 
      effects at early stage of systemic inflammatory response.
FAU - Huang, Jian
AU  - Huang J
AD  - Intensive Care Unit, Daping Hospital Third Military Medical University, Chongqing 
      400042, PR China.
FAU - Zhang, Nian-Chun
AU  - Zhang NC
FAU - Zhou, Jian
AU  - Zhou J
FAU - Yang, Zhi-Huan
AU  - Yang ZH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Shao Shang Za Zhi
JT  - Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
JID - 100959418
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Endotoxemia/blood/*therapy
MH  - Interleukin-10/*blood
MH  - Lipopolysaccharides
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - *Vagus Nerve Stimulation
EDAT- 2008/09/13 09:00
MHDA- 2009/07/08 09:00
CRDT- 2008/09/13 09:00
PHST- 2008/09/13 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PHST- 2008/09/13 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Shao Shang Za Zhi. 2008 Apr;24(2):99-101.