PMID- 18786515
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1239
DP  - 2008 Nov 6
TI  - Characteristics of dual specificity phosphatases mRNA regulation by 
      3,4-methylenedioxymethamphetamine acute treatment in mice striatum.
PG  - 42-8
LID - 10.1016/j.brainres.2008.08.050 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug that has 
      rewarding properties in rodents but little is known about its effects at the 
      cellular and molecular levels. We have previously shown that the ERK pathway is 
      important for the regulation in gene expression observed in mice striatum after 
      acute treatment with MDMA. Interestingly, three dual specificity phosphatases 
      were found among the genes modulated by MDMA acute treatment. In this study we 
      investigated the signalling pathways leading to the up-regulation of these three 
      mRNAs and the kinetics of their regulation. We found that the increase in Dusp14 
      mRNA depends on the activation of ERK and lasts longer than those of Dusp1 and 
      Dusp5. The modulation of the three studied Dusps depends partially on the 
      activation of D1 receptors but is independent of the activation of D2 receptors. 
      These results suggest that at least two separate signalling cascades lead to the 
      up-regulation of MAPK phosphatase mRNAs. The increase of Dusp1 and Dusp5 mRNAs is 
      not controlled by ERK activation while that of Dusp14 is a direct 
      negative-feedback mechanism of MDMA-induced ERK signalling. Both mechanisms 
      converge to increase the expression levels of phosphatases able to inactivate 
      ERK.
FAU - Marie-Claire, Cynthia
AU  - Marie-Claire C
AD  - Laboratoire de Neuropsychopharmacologie des addictions (UMR CNRS 7157, INSERM 
      U705) Universite Paris Descartes, Faculte de Pharmacie, Paris, France.
FAU - Benturquia, Nadia
AU  - Benturquia N
FAU - Lundqvist, Ann
AU  - Lundqvist A
FAU - Courtin, Cindie
AU  - Courtin C
FAU - Noble, Florence
AU  - Noble F
LA  - eng
PT  - Journal Article
DEP - 20080828
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hallucinogens)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 3.1.3.48 (Dual Specificity Phosphatase 1)
RN  - EC 3.1.3.48 (Dual-Specificity Phosphatases)
RN  - EC 3.1.3.48 (Dusp1 protein, mouse)
RN  - EC 3.1.3.48 (Dusp14 protein, mouse)
RN  - EC 3.1.3.48 (Dusp5 protein, mouse)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/*drug effects/enzymology/physiology
MH  - Dual Specificity Phosphatase 1/genetics/metabolism
MH  - Dual-Specificity Phosphatases/*genetics/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Hallucinogens/*pharmacology
MH  - Kinetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Receptors, Dopamine D1/metabolism
MH  - Receptors, Dopamine D2/metabolism
MH  - Signal Transduction/drug effects
MH  - Up-Regulation/*drug effects/physiology
EDAT- 2008/09/13 09:00
MHDA- 2010/01/13 06:00
CRDT- 2008/09/13 09:00
PHST- 2008/05/15 00:00 [received]
PHST- 2008/08/07 00:00 [revised]
PHST- 2008/08/18 00:00 [accepted]
PHST- 2008/09/13 09:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PHST- 2008/09/13 09:00 [entrez]
AID - S0006-8993(08)02083-0 [pii]
AID - 10.1016/j.brainres.2008.08.050 [doi]
PST - ppublish
SO  - Brain Res. 2008 Nov 6;1239:42-8. doi: 10.1016/j.brainres.2008.08.050. Epub 2008 
      Aug 28.