PMID- 18787351
OWN - NLM
STAT- MEDLINE
DCOM- 20081208
LR  - 20091119
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 31
IP  - 8-9
DP  - 2008 Sep
TI  - Trisomy 22 as the sole abnormality is an important marker for the diagnosis of 
      acute myeloid leukemia with inversion 16.
PG  - 440-4
LID - 10.1159/000141917 [doi]
AB  - BACKGROUND: The inversion of chromosome 16 (inv(16) (p13q22)) and the related 
      t(16;16)(p13;q22) are chromosomal aberrations observed in approximately 10% of de 
      novo acute myeloid leukemia (AML), mostly classified as M4Eo subtype, and 
      associated with a relatively favorable outcome. However, it is a cryptic 
      rearrangement and often difficult to recognize in conventional cytogenetics (CC). 
      Trisomy 22 is an uncommon karyotypic aberration in AML and is often associated 
      with inv(16)(p13q22). The aim of this study was to explore the value of trisomy 
      22 in the diagnosis of AML with inv(16). PATIENTS AND METHODS: Dual-color 
      interphase fluorescence in situ hybridization (FISH) was performed in 19 AML 
      cases with trisomy 22 abnormality shown by R-banding CC. The probe was a 
      two-color break-apart probe for CBFbeta on the centromeric side and the telomeric 
      side. RESULTS: R-banding CC did not reveal inv(16) in any of the 19 AML with 
      trisomy 22, but FISH analysis showed inv(16) in 11 cases and del(16)(q22) in 1 
      case. Among the 11 cases with inv(16), 9 showed trisomy 22 as the sole 
      abnormality, 1 was complicated by trisomy 8, and 1 was del(16)(q22). CONCLUSION: 
      This study further confirmed that trisomy 22 as the sole abnormality can be 
      regarded as an important marker for inv(16) in AML.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing, China.
FAU - Zhou, Hui-Fen
AU  - Zhou HF
FAU - Fan, Lei
AU  - Fan L
FAU - Qian, Si-Xuan
AU  - Qian SX
FAU - Chen, Li-Juan
AU  - Chen LJ
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Zhang, Su-Jiang
AU  - Zhang SJ
FAU - Li, Jian-Yong
AU  - Li JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080731
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chromosome Inversion/*genetics
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Trisomy/*diagnosis/*genetics
MH  - Young Adult
EDAT- 2008/09/13 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/09/13 09:00
PHST- 2008/09/13 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/13 09:00 [entrez]
AID - 000141917 [pii]
AID - 10.1159/000141917 [doi]
PST - ppublish
SO  - Onkologie. 2008 Sep;31(8-9):440-4. doi: 10.1159/000141917. Epub 2008 Jul 31.