PMID- 18787961
OWN - NLM
STAT- MEDLINE
DCOM- 20090113
LR  - 20211020
IS  - 1573-7276 (Electronic)
IS  - 0262-0898 (Linking)
VI  - 25
IP  - 8
DP  - 2008
TI  - Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node 
      metastases in laryngeal squamous cell carcinoma in Chinese patients.
PG  - 887-92
LID - 10.1007/s10585-008-9207-x [doi]
AB  - BACKGROUND: CyclinD1 and p16 are involved in the regulation of G1 checkpoint and 
      may play an important role in the tumorgenesis of laryngeal squamous cell 
      carcinoma (LSCC). Previous studies have examined the level of expression of 
      cyclinD1 or p16 in LSCC but no such information is available for their relation 
      and their correlation with lymph node metastasis in Chinese patients. PATIENTS 
      AND METHODS: A total of 58 patients underwent surgical resection of laryngeal 
      tumours in the Department of Otolaryngology, Qilu Hospital Shandong University 
      between January 2001 and December 2002. All pathologic specimens were available 
      for immunohistochemical study using antibodies against cyclinD1 and p16. RESULTS: 
      Compared with normal epithelium, expression of CyclinD1 in the LSCC was 
      significantly higher (62.1% vs. 10.0%, P < 0.05), expression of p16 was 
      significantly lower (48.3% vs. 90.0%, P < 0.05); CyclinD1 expression in LSCC was 
      up-regulated in TNM classification (r (s) = 0.409, P < 0.05) as well as with 
      cervical lymph node metastases (r (s) = 0.294, P < 0.05); p16 expression in LSCC 
      was down-regulated with cervical lymph node metastases (r (s) = -0.275, P < 
      0.05); negative significant correlation between p16 immunostaining and CyclinD1 
      was observed in LSCC (r (s) = -0.331, P < 0.05). CONCLUSION: There was a negative 
      correlation between CyclinD1 expression and p16 expression in LSCC. The 
      over-expression of CyclinD1 and the under-expression of p16 may play a 
      significant role in the incidence and development of LSCC and may be important 
      indicators for cervical lymph node metastases in Chinese patients of LSCC.
FAU - Fu, Zhi-jie
AU  - Fu ZJ
AD  - Department of Otorhinolaryngology, Shandong Provincial Qianfoshan Hospital, 
      Clinical Medical College of Shandong University, Jinan, China.
FAU - Ma, Zhi-yong
AU  - Ma ZY
FAU - Wang, Qi-rong
AU  - Wang QR
FAU - Lei, Da-peng
AU  - Lei DP
FAU - Wang, Rong
AU  - Wang R
FAU - Liu, Chun-xi
AU  - Liu CX
FAU - Pan, Xin-liang
AU  - Pan XL
LA  - eng
PT  - Journal Article
DEP - 20080912
PL  - Netherlands
TA  - Clin Exp Metastasis
JT  - Clinical & experimental metastasis
JID - 8409970
RN  - 0 (CCND1 protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - China/epidemiology
MH  - Cyclin D1/*metabolism
MH  - Cyclin-Dependent Kinase Inhibitor p16/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 2008/09/13 09:00
MHDA- 2009/01/14 09:00
CRDT- 2008/09/13 09:00
PHST- 2007/09/02 00:00 [received]
PHST- 2008/08/21 00:00 [accepted]
PHST- 2008/09/13 09:00 [pubmed]
PHST- 2009/01/14 09:00 [medline]
PHST- 2008/09/13 09:00 [entrez]
AID - 10.1007/s10585-008-9207-x [doi]
PST - ppublish
SO  - Clin Exp Metastasis. 2008;25(8):887-92. doi: 10.1007/s10585-008-9207-x. Epub 2008 
      Sep 12.